Skip to main content
Top
Published in: Advances in Therapy 11/2016

Open Access 01-11-2016 | Original Research

Perceptions of Oncologists, Healthcare Policy Makers, Patients and the General Population on the Value of Pharmaceutical Treatments in Oncology

Authors: José A. Sacristán, Luís Lizan, Marta Comellas, Pilar Garrido, Cristina Avendaño, Juan J. Cruz-Hernández, Javier Espinosa, Tatiana Dilla

Published in: Advances in Therapy | Issue 11/2016

Login to get access

Abstract

Introduction

The purpose of this study was to explore the main factors explaining the relative weight of the different attributes that determine the value of oncologic treatments from the different perspectives of healthcare policy makers (HCPM), oncologists, patients and the general population in Spain.

Methods

Structured interviews were conducted to assess: (1) the importance of the attributes on treatment choice when comparing a new cancer drug with a standard cancer treatment; (2) the importance of survival, quality of life (QoL), costs and innovation in cancer; and (3) the most worrying side effects related to cancer drugs.

Results

A total of 188 individuals participated in the study. For all participants, when choosing treatments, the best rated characteristics were greater efficacy, greater safety, treatment adaptation to patients’ individual requirements and the rapid reincorporation of patients to their daily activities. There were important differences among participants in their opinion about survival, QoL and cost. In general, oncologists, patients, and the general population gave greater value to gains in QoL than healthcare policy makers. Compared to other participants healthcare policy makers gave greater importance to the economic impact related to oncology treatments.

Conclusions

Gains in QoL, survival, safety, cost and innovation are perceived differently by different groups of stakeholders. It is recommended to consider the perspective of different stakeholders in the assessment of a new cancer drugs to obtain more informed decisions when deciding on the most appropriate treatment to use.

Funding

Eli Lilly & Co, Madrid (Spain).
Literature
1.
go back to reference Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359–86.CrossRefPubMed Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359–86.CrossRefPubMed
4.
go back to reference Hoverman JR, Cartwright TH, Patt DA. Pathways, outcomes, and costs in colon cancer: retrospective evaluations in two distinct databases. J Oncol Pract. 2011;7(3 Suppl):52s–9s.CrossRefPubMedPubMedCentral Hoverman JR, Cartwright TH, Patt DA. Pathways, outcomes, and costs in colon cancer: retrospective evaluations in two distinct databases. J Oncol Pract. 2011;7(3 Suppl):52s–9s.CrossRefPubMedPubMedCentral
7.
go back to reference Schnipper LE, Davidson NE, Wollins DS, Tyne C, Blayney DW, Blum D, et al. American Society of Clinical Oncology Statement: a conceptual framework to assess the value of cancer treatment options. J Clin Oncol. 2015;33(23):2563–77.CrossRefPubMedPubMedCentral Schnipper LE, Davidson NE, Wollins DS, Tyne C, Blayney DW, Blum D, et al. American Society of Clinical Oncology Statement: a conceptual framework to assess the value of cancer treatment options. J Clin Oncol. 2015;33(23):2563–77.CrossRefPubMedPubMedCentral
8.
go back to reference Cherny NI, Sullivan R, Dafni U, Kerst JM, Sobrero A, Zielinski C, et al. A standardised, generic, validated approach to stratify the magnitude of clinical benefit that can be anticipated from anti-cancer therapies: the European Society for Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS). Ann Oncol. 2015;26(8):1547–73.CrossRefPubMed Cherny NI, Sullivan R, Dafni U, Kerst JM, Sobrero A, Zielinski C, et al. A standardised, generic, validated approach to stratify the magnitude of clinical benefit that can be anticipated from anti-cancer therapies: the European Society for Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS). Ann Oncol. 2015;26(8):1547–73.CrossRefPubMed
9.
10.
go back to reference Marshall B, Cardon P, Poddar A, Fontenot R. Does sample size matter in qualitative research? A review of qualitative interviews in is research. J Comput Inform Syst. 2013;54(1):11–22. Marshall B, Cardon P, Poddar A, Fontenot R. Does sample size matter in qualitative research? A review of qualitative interviews in is research. J Comput Inform Syst. 2013;54(1):11–22.
11.
go back to reference Mao JJ, Chung A, Benton A, Hill S, Ungar L, Leonard CE, Hennessy S, Holmes JH. Online discussion of drug side effects and discontinuation among breast cancer survivors. Pharmacoepidemiol Drug Saf. 2013;22(3):256–62.CrossRefPubMedPubMedCentral Mao JJ, Chung A, Benton A, Hill S, Ungar L, Leonard CE, Hennessy S, Holmes JH. Online discussion of drug side effects and discontinuation among breast cancer survivors. Pharmacoepidemiol Drug Saf. 2013;22(3):256–62.CrossRefPubMedPubMedCentral
13.
go back to reference Dilla T, Lizan L, Paz S, Garrido P, Avendaño C, Cruz-Hernández JJ, Espinosa J, Sacristán JA. Do new cancer drugs offer good value for money? The perspectives of oncologists, health care policy makers, patients, and the general population. Patient Prefer Adher. 2015;18(10):1–7. Dilla T, Lizan L, Paz S, Garrido P, Avendaño C, Cruz-Hernández JJ, Espinosa J, Sacristán JA. Do new cancer drugs offer good value for money? The perspectives of oncologists, health care policy makers, patients, and the general population. Patient Prefer Adher. 2015;18(10):1–7.
14.
go back to reference Kozminski MA, Neumann PJ, Nadler ES, Jankovic A, Ubel PA. How long and how well: oncologists’ attitudes toward the relative value of life-prolonging v. quality of life-enhancing treatments. Med Decis Making. 2011;31(3):380–5.CrossRefPubMed Kozminski MA, Neumann PJ, Nadler ES, Jankovic A, Ubel PA. How long and how well: oncologists’ attitudes toward the relative value of life-prolonging v. quality of life-enhancing treatments. Med Decis Making. 2011;31(3):380–5.CrossRefPubMed
15.
go back to reference Greenberg D, Hammerman A, Vinker S, Shani A, Yermiahu Y, et al. Which is more valuable, longer survival or better quality of life? Israeli oncologists’ and family physicians’ attitudes toward the relative value of new cancer and congestive heart failure interventions. Value Health. 2013;16(5):842–7.CrossRefPubMed Greenberg D, Hammerman A, Vinker S, Shani A, Yermiahu Y, et al. Which is more valuable, longer survival or better quality of life? Israeli oncologists’ and family physicians’ attitudes toward the relative value of new cancer and congestive heart failure interventions. Value Health. 2013;16(5):842–7.CrossRefPubMed
17.
go back to reference Schickedanz A. Of value: a discussion of cost, communication, and evidence to improve cancer care. Oncologist. 2010;15(Suppl 1):73–9.CrossRefPubMed Schickedanz A. Of value: a discussion of cost, communication, and evidence to improve cancer care. Oncologist. 2010;15(Suppl 1):73–9.CrossRefPubMed
18.
19.
go back to reference Zafar SY, Abernethy AP. Financial toxicity, part I: a new name for a growing problem. Oncology (Williston Park). 2013;27(2):80–149.PubMedPubMedCentral Zafar SY, Abernethy AP. Financial toxicity, part I: a new name for a growing problem. Oncology (Williston Park). 2013;27(2):80–149.PubMedPubMedCentral
20.
go back to reference Zafar SY, Peppercorn JM, Schrag D, Taylor DH, Goetzinger AM, Zhong X, Abernethy AP. The financial toxicity of cancer treatment: a pilot study assessing out-of-pocket expenses and the insured cancer patient’s experience. Oncologist. 2013;18(4):381–90.CrossRefPubMedPubMedCentral Zafar SY, Peppercorn JM, Schrag D, Taylor DH, Goetzinger AM, Zhong X, Abernethy AP. The financial toxicity of cancer treatment: a pilot study assessing out-of-pocket expenses and the insured cancer patient’s experience. Oncologist. 2013;18(4):381–90.CrossRefPubMedPubMedCentral
21.
go back to reference Herikson N, Tuzzio L, Loggers ET, Miyoshi J, Buist D. Patient and oncologist discussions about cancer care costs. Support Care Cancer. 2014;22(4):961–7.CrossRef Herikson N, Tuzzio L, Loggers ET, Miyoshi J, Buist D. Patient and oncologist discussions about cancer care costs. Support Care Cancer. 2014;22(4):961–7.CrossRef
22.
go back to reference Krammer R, Heinzerling L. Therapy preferences in melanoma treatment—willingness to pay and preference of quality versus length of life of patients, physicians and healthy controls. Plos One. 2014;9(11):e111237.CrossRefPubMedPubMedCentral Krammer R, Heinzerling L. Therapy preferences in melanoma treatment—willingness to pay and preference of quality versus length of life of patients, physicians and healthy controls. Plos One. 2014;9(11):e111237.CrossRefPubMedPubMedCentral
Metadata
Title
Perceptions of Oncologists, Healthcare Policy Makers, Patients and the General Population on the Value of Pharmaceutical Treatments in Oncology
Authors
José A. Sacristán
Luís Lizan
Marta Comellas
Pilar Garrido
Cristina Avendaño
Juan J. Cruz-Hernández
Javier Espinosa
Tatiana Dilla
Publication date
01-11-2016
Publisher
Springer Healthcare
Published in
Advances in Therapy / Issue 11/2016
Print ISSN: 0741-238X
Electronic ISSN: 1865-8652
DOI
https://doi.org/10.1007/s12325-016-0415-5

Other articles of this Issue 11/2016

Advances in Therapy 11/2016 Go to the issue