01-04-2017 | Consensus paper
Current Opinions and Areas of Consensus on the Role of the Cerebellum in Dystonia
Published in: The Cerebellum | Issue 2/2017
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A role for the cerebellum in causing ataxia, a disorder characterized by uncoordinated movement, is widely accepted. Recent work has suggested that alterations in activity, connectivity, and structure of the cerebellum are also associated with dystonia, a neurological disorder characterized by abnormal and sustained muscle contractions often leading to abnormal maintained postures. In this manuscript, the authors discuss their views on how the cerebellum may play a role in dystonia. The following topics are discussed:
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The relationships between neuronal/network dysfunctions and motor abnormalities in rodent models of dystonia.
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Data about brain structure, cerebellar metabolism, cerebellar connections, and noninvasive cerebellar stimulation that support (or not) a role for the cerebellum in human dystonia.
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Connections between the cerebellum and motor cortical and sub-cortical structures that could support a role for the cerebellum in dystonia.
Overall points of consensus include:
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Neuronal dysfunction originating in the cerebellum can drive dystonic movements in rodent model systems.
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Imaging and neurophysiological studies in humans suggest that the cerebellum plays a role in the pathophysiology of dystonia, but do not provide conclusive evidence that the cerebellum is the primary or sole neuroanatomical site of origin.