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01-11-2015 | Original Article

Stimulation of the subthalamic nucleus engages the cerebellum for motor function in parkinsonian rats

Authors: Alexander C. Sutton, Katherine A. O’Connor, Julie G. Pilitsis, Damian S. Shin

Published in: Brain Structure and Function | Issue 6/2015

Abstract

Deep brain stimulation (DBS) is effective in managing motor symptoms of Parkinson’s disease in well-selected individuals. Recently, research has shown that DBS in the basal ganglia (BG) can alter neural circuits beyond the traditional basal ganglia-thalamus-cortical (BG-TH-CX) loop. For instance, functional imaging showed alterations in cerebellar activity with DBS in the subthalamic nucleus (STN). However, these imaging studies revealed very little about how cell-specific cerebellar activity responds to STN stimulation or if these changes contribute to its efficacy. In this study, we assess whether STN-DBS provides efficacy in managing motor symptoms in Parkinson’s disease by recruiting cerebellar activity. We do this by applying STN-DBS in hemiparkinsonian rats and simultaneously recording neuronal activity from the STN, brainstem and cerebellum. We found that STN neurons decreased spiking activity by 55 % during DBS (P = 0.038), which coincided with a decrease in most pedunculopontine tegmental nucleus and Purkinje neurons by 29 % (P < 0.001) and 28 % (P = 0.003), respectively. In contrast, spike activity in the deep cerebellar nuclei increased 45 % during DBS (P < 0.001), which was likely from reduced afferent activity of Purkinje cells. Then, we applied STN-DBS at sub-therapeutic current along with stimulation of the deep cerebellar nuclei and found similar improvement in forelimb akinesia as with therapeutic STN-DBS alone. This suggests that STN-DBS can engage cerebellar activity to improve parkinsonian motor symptoms. Our study is the first to describe how STN-DBS in Parkinson’s disease alters cerebellar activity using electrophysiology in vivo and reveal a potential for stimulating the cerebellum to potentiate deep brain stimulation of the subthalamic nucleus.

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Title: Stimulation of the subthalamic nucleus engages the cerebellum for motor function in parkinsonian rats
Authors: Alexander C. Sutton
Katherine A. O’Connor
Julie G. Pilitsis
Damian S. Shin
Publication date: 01-11-2015
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 6/2015
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-014-0876-8

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Stimulation of the subthalamic nucleus engages the cerebellum for motor function in parkinsonian rats

Abstract

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Abstract

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