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Indian Journal of Hematology and Blood Transfusion
Published in: Indian Journal of Hematology and Blood Transfusion 2/2021

01-04-2021 | Aplastic Anemia | Original Article

Association of Interleukin-1β-31C/T, -511T/C and -3954C/T Single Nucleotide Polymorphism and Their Blood Plasma Level in Acquired Aplastic Anemia

Authors: Saurabh Shukla, Anil Kumar Tripathi, Shailendra Prasad Verma, Deependra Kumar Yadav, R. K. Tripathi, Shweta Maurya, Nidhi Awasthi

Published in: Indian Journal of Hematology and Blood Transfusion | Issue 2/2021

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Abstract

Aplastic anemia (AA) is an immune-mediated disorder in which hematopoietic stem and progenitor cells are targeted by a number of cellular and molecular pathways. This case control study aims to investigate the association of interleukin-1beta (IL-1β) gene polymorphisms, (IL-1β-31, IL-1β-511 and IL-1β-3954) and their plasma levels with acquired AA. Genotyping was done by Restricted Fragment Length Polymorphism (PCR–RFLP) method and IL-1β plasma levels were evaluated in peripheral blood using ELISA. Increased level of IL-1β was reported to be significant in cases as compared to controls. The susceptibility of developing AA was higher in the cases for IL-1β-3954 genotype. IL-1β-511 genotype showed significant association with the severity groups of AA. No significant association was noticed in responder versus non-responder group. Plasma level of IL-1β gene was found to be significantly higher in severe and very-severe group of AA versus control group. Our findings suggest that IL-1β gene and its genotypes might be involved in the pathophysiology of AA and play a central role in the etiopathogenesis of AA.
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Metadata
Title
Association of Interleukin-1β-31C/T, -511T/C and -3954C/T Single Nucleotide Polymorphism and Their Blood Plasma Level in Acquired Aplastic Anemia
Authors
Saurabh Shukla
Anil Kumar Tripathi
Shailendra Prasad Verma
Deependra Kumar Yadav
R. K. Tripathi
Shweta Maurya
Nidhi Awasthi
Publication date
01-04-2021
Publisher
Springer India
Keyword
Aplastic Anemia
Published in
Indian Journal of Hematology and Blood Transfusion / Issue 2/2021
Print ISSN: 0971-4502
Electronic ISSN: 0974-0449
DOI
https://doi.org/10.1007/s12288-020-01281-0

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