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Indian Journal of Hematology and Blood Transfusion
Published in: Indian Journal of Hematology and Blood Transfusion 4/2019

01-10-2019 | Thrombocytopenia | Short Communication

High Prevalence of Celiac Disease in Patients with Immune Thrombocytopenia

Authors: Parathan Karunakaran, Rakesh Kochhar, Sadhna Lal, Ram V. Nampoothiri, Neelam Varma, Subhash Varma, Pankaj Malhotra

Published in: Indian Journal of Hematology and Blood Transfusion | Issue 4/2019

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Abstract

Celiac disease (CD) is known to be associated with several autoimmune disorders. We studied the prevalence of subclinical CD among patients with immune thrombocytopenia (ITP) as compared to general population. Cases of primary ITP between the age group of 18–60 years were studied. Besides clinical examination, all patients underwent serology testing for tissue transglutaminase antibody (tTG) IgA and anti-endomysial antibodies IgA. The diagnosis of CD was made if both antibodies were positive. Healthy subjects acted as controls and underwent serological testing for tTG IgA. Seventy-nine primary ITP and 316 healthy subjects underwent serology testing for CD. Four patients of primary ITP (4/79) were positive for both serology as compared to 2 (2/316) healthy controls [odds ratio 8.37 (CI 1.50–46.47, p < 0.005)]. Among the ITP cases only one had clinical symptoms of CD while none of the healthy controls had symptoms of CD. There is a significantly higher prevalence of subclinical CD in patients with ITP. Since the prevalence of CD is known to vary among different geographical zones, we suggest further studies on screening of ITP patients for CD in areas of high prevalence.
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Metadata
Title
High Prevalence of Celiac Disease in Patients with Immune Thrombocytopenia
Authors
Parathan Karunakaran
Rakesh Kochhar
Sadhna Lal
Ram V. Nampoothiri
Neelam Varma
Subhash Varma
Pankaj Malhotra
Publication date
01-10-2019
Publisher
Springer India
Published in
Indian Journal of Hematology and Blood Transfusion / Issue 4/2019
Print ISSN: 0971-4502
Electronic ISSN: 0974-0449
DOI
https://doi.org/10.1007/s12288-019-01120-x

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