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Indian Journal of Hematology and Blood Transfusion

Published in:

01-06-2016 | Case Report

Leukemic Transformation of Severe Aplastic Anemia Following Matched Allogenic Stem Cell Transplantation, Transplanted Again in CR 1

Authors: Prabhu Manivannan, Abhishek Purohit, Venkatesan Somasundaram, Ankur Ahuja, Mukul Aggarwal, Rajiv Kumar, Pawan Kumar Singh, Hara Prasad Pati, Pravas Mishra, Tulika Seth, Manoranjan Mahapatra

Published in: Indian Journal of Hematology and Blood Transfusion | Special Issue 1/2016

Abstract

Aplastic anemia (AA) is a life-threatening bone marrow failure disorder, if untreated, is associated with very high mortality. Allogenic bone marrow transplantation (BMT) is the standard of care for severe aplastic anemia (SAA) patients those who are younger than 40 years of age. The development of secondary malignancies in post-BMT setting for AA is a rare, however, well documented phenomenon. Among the secondary malignancies, development of acute myeloid leukemia is even rarer entity. Here we report a case of acute myeloid leukemia following human leucocyte antigen (HLA) matched sibling peripheral blood stem cell transplant (PBSCT) in a case of SAA. The patient achieved complete remission (CR) following chemotherapy and in CR1, a second HLA matched PBSCT from a different donor was offered. The patient is presently in remission at day +180 post-PBSCT.

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Title: Leukemic Transformation of Severe Aplastic Anemia Following Matched Allogenic Stem Cell Transplantation, Transplanted Again in CR 1
Authors: Prabhu Manivannan
Abhishek Purohit
Venkatesan Somasundaram
Ankur Ahuja
Mukul Aggarwal
Rajiv Kumar
Pawan Kumar Singh
Hara Prasad Pati
Pravas Mishra
Tulika Seth
Manoranjan Mahapatra
Publication date: 01-06-2016
Publisher: Springer India
Published in: Indian Journal of Hematology and Blood Transfusion / Issue Special Issue 1/2016
Print ISSN: 0971-4502
Electronic ISSN: 0974-0449
DOI: https://doi.org/10.1007/s12288-014-0484-z

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