Skip to main content
Top
Published in: Current Fungal Infection Reports 4/2017

01-12-2017 | Clinical Mycology Lab Issues (S Córdoba, Section Editor)

Contribution of the National Mycology Laboratory Network to Surveillance of Cryptococcosis in Argentina

Authors: Mariana Mazza, Graciela O. Davel, Constanza G. Taverna, Nicolás Refojo, Cristina E. Canteros, Nadia S. Bueno, Guillermina Isla, Ruben A. Abrantes, Alejandra I. Hevia, Adriana I. Toranzo, National Mycology Laboratory Network of Argentina (NMLN)

Published in: Current Fungal Infection Reports | Issue 4/2017

Login to get access

Abstract

Purpose of Review

Cryptococcal meningitis is the most common fungal infection of the central nervous system and the third most frequent neurological complication in AIDS patients. To understand the Argentinean epidemiology of cryptococcosis, several efforts have been made by the National Reference Laboratory in Clinical Mycology.

Recent Findings

In Argentina, reports of distribution and frequency of Cryptococcus neoformans and Cryptococcus gattii isolates are scarce and very little is known about its circulating genotypes and mating types. The National Mycology Laboratory Network and the National Reference Laboratory in Clinical Mycology joined forces to estimate the prevalence of cryptococcosis and to obtain and to analyse epidemiological data of this important fungal infection.

Summary

Data presented here were recovered from 1998 to 2016 and represents an approximation to the actual situation of cryptococcosis in Argentina. These results could be useful to design future investigations.
Appendix
Available only for authorised users
Literature
1.
go back to reference Davel G, Canteros CE. Epidemiological status of mycoses in the Argentine Republic. Rev Argent Microbiol. 2007;39:28–33.PubMed Davel G, Canteros CE. Epidemiological status of mycoses in the Argentine Republic. Rev Argent Microbiol. 2007;39:28–33.PubMed
2.
go back to reference Cogliati M. Global molecular epidemiology of Cryptococcus neoformans and Cryptococcus gattii: an atlas of the molecular types. Scientifica. 2013;2013:675213.CrossRefPubMedPubMedCentral Cogliati M. Global molecular epidemiology of Cryptococcus neoformans and Cryptococcus gattii: an atlas of the molecular types. Scientifica. 2013;2013:675213.CrossRefPubMedPubMedCentral
3.
go back to reference Kwon-Chung KJ, Fraser JA, Doering TL, Wang Z, Janbon G, Idnurm A, et al. Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis. Cold Spring Harb Perspect Med. 2014;a019760:4. Kwon-Chung KJ, Fraser JA, Doering TL, Wang Z, Janbon G, Idnurm A, et al. Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis. Cold Spring Harb Perspect Med. 2014;a019760:4.
4.
go back to reference Perfect JR, Bicanic T. Cryptococcosis diagnosis and treatment: what do we know now. Fungal Genet Biol. 2015;78:49–54.CrossRefPubMed Perfect JR, Bicanic T. Cryptococcosis diagnosis and treatment: what do we know now. Fungal Genet Biol. 2015;78:49–54.CrossRefPubMed
5.
go back to reference •• Hagen F, Khayhan K, Theelen B, Kolecka A, Polacheck I, Sionov E, et al. Recognition of seven species in the Cryptococcus gattii/Cryptococcus neoformans species complex. Fungal Genet Biol. 2015;78:16–48. A large survey about the diversity of Cryptococcus neoformans and C. gattii species complex and a proposal for taxonomic status of their species. CrossRefPubMed •• Hagen F, Khayhan K, Theelen B, Kolecka A, Polacheck I, Sionov E, et al. Recognition of seven species in the Cryptococcus gattii/Cryptococcus neoformans species complex. Fungal Genet Biol. 2015;78:16–48. A large survey about the diversity of Cryptococcus neoformans and C. gattii species complex and a proposal for taxonomic status of their species. CrossRefPubMed
6.
go back to reference Kwon-Chung KJ, Bennett JE, Wickes BL, Meyer W, Cuomo CA, Wollenburg KR, et al. The case for adopting the “species complex” nomenclature for the etiologic agents of Cryptococcosis. mSphere. 2017;2:e00357–16.CrossRefPubMedPubMedCentral Kwon-Chung KJ, Bennett JE, Wickes BL, Meyer W, Cuomo CA, Wollenburg KR, et al. The case for adopting the “species complex” nomenclature for the etiologic agents of Cryptococcosis. mSphere. 2017;2:e00357–16.CrossRefPubMedPubMedCentral
7.
go back to reference Casadevall A, Freij JB, Hann-Soden C, Taylor J. Continental drift and speciation of the Cryptococcus neoformans and Cryptococcus gattii species complexes. mSphere. 2017;2:e00103–17.PubMedPubMedCentral Casadevall A, Freij JB, Hann-Soden C, Taylor J. Continental drift and speciation of the Cryptococcus neoformans and Cryptococcus gattii species complexes. mSphere. 2017;2:e00103–17.PubMedPubMedCentral
8.
go back to reference Firacative C, Roe CC, Malik R, Ferreira-Paim K, Escandón P, Sykes JE, et al. MLST and whole-genome-based population analysis of Cryptococcus gattii VGIII links clinical, veterinary and environmental strains, and reveals divergent serotype specific sub-populations and distant ancestors. PLoS Negl Trop Dis. 2016;10:e0004861.CrossRefPubMedPubMedCentral Firacative C, Roe CC, Malik R, Ferreira-Paim K, Escandón P, Sykes JE, et al. MLST and whole-genome-based population analysis of Cryptococcus gattii VGIII links clinical, veterinary and environmental strains, and reveals divergent serotype specific sub-populations and distant ancestors. PLoS Negl Trop Dis. 2016;10:e0004861.CrossRefPubMedPubMedCentral
9.
go back to reference Aminnejad M, Cogliati M, Duan S, Arabatzis M, Tintelnot K, Castañeda E, et al. Identification and characterization of VNI/VNII and novel VNII/VNIV hybrids and impact of hybridization on virulence and antifungal susceptibility within the C. neoformans/C. gattii species complex. PLoS One. 2016;11:e0163955.CrossRefPubMedPubMedCentral Aminnejad M, Cogliati M, Duan S, Arabatzis M, Tintelnot K, Castañeda E, et al. Identification and characterization of VNI/VNII and novel VNII/VNIV hybrids and impact of hybridization on virulence and antifungal susceptibility within the C. neoformans/C. gattii species complex. PLoS One. 2016;11:e0163955.CrossRefPubMedPubMedCentral
10.
go back to reference Lin X, Hull CM, Heitman J. Sexual reproduction between partners of the same mating type in Cryptococcus neoformans. Nature. 2005;434:1017–21.CrossRefPubMed Lin X, Hull CM, Heitman J. Sexual reproduction between partners of the same mating type in Cryptococcus neoformans. Nature. 2005;434:1017–21.CrossRefPubMed
11.
go back to reference Negroni RBA. Study of the first autochthonous case of cryptococcosis in Argentina by Cryptococcus neoformans var. gattii. Rev Iberoam Micol. 1990;7:39–42. Negroni RBA. Study of the first autochthonous case of cryptococcosis in Argentina by Cryptococcus neoformans var. gattii. Rev Iberoam Micol. 1990;7:39–42.
12.
go back to reference Bava AJ, Negroni R. The epidemiological characteristics of 105 cases of cryptococcosis diagnosed in the Republic of Argentina between 1981-1990. Rev Inst Med Trop Sao Paulo. 1992;34:335–40.CrossRefPubMed Bava AJ, Negroni R. The epidemiological characteristics of 105 cases of cryptococcosis diagnosed in the Republic of Argentina between 1981-1990. Rev Inst Med Trop Sao Paulo. 1992;34:335–40.CrossRefPubMed
13.
go back to reference Davel G, Abrantes R, Brudny M, Córdoba S, Rodero L, Canteros CE, et al. 1st environmental isolation of Cryptococcus neoformans var. gattii in Argentina. Rev Argent Microbiol. 2003;35:110–2.PubMed Davel G, Abrantes R, Brudny M, Córdoba S, Rodero L, Canteros CE, et al. 1st environmental isolation of Cryptococcus neoformans var. gattii in Argentina. Rev Argent Microbiol. 2003;35:110–2.PubMed
14.
go back to reference Refojo N, Perrotta D, Brudny M, Abrantes R, Hevia AI, Davel G. Isolation of Cryptococcus neoformans and Cryptococcus gattii from trunk hollows of living trees in Buenos Aires City, Argentina. Med Mycol. 2009;47:177–84.CrossRefPubMed Refojo N, Perrotta D, Brudny M, Abrantes R, Hevia AI, Davel G. Isolation of Cryptococcus neoformans and Cryptococcus gattii from trunk hollows of living trees in Buenos Aires City, Argentina. Med Mycol. 2009;47:177–84.CrossRefPubMed
15.
go back to reference Mazza M, Refojo N, Bosco-Borgeat ME, Taverna CG, Trovero AC, Rogé A, et al. Cryptococcus gattii in urban trees from cities in North-eastern Argentina. Mycoses. 2013;56:646–50.CrossRefPubMed Mazza M, Refojo N, Bosco-Borgeat ME, Taverna CG, Trovero AC, Rogé A, et al. Cryptococcus gattii in urban trees from cities in North-eastern Argentina. Mycoses. 2013;56:646–50.CrossRefPubMed
16.
go back to reference Cattana ME, Sosa M, de LÁ Fernández M, Rojas F, Mangiaterra M, Giusiano G. Native trees of the Northeast Argentine: natural hosts of the Cryptococcus neoformans-Cryptococcus gattii species complex. Rev Iberoam Micol. 2014;31:188–92.CrossRefPubMed Cattana ME, Sosa M, de LÁ Fernández M, Rojas F, Mangiaterra M, Giusiano G. Native trees of the Northeast Argentine: natural hosts of the Cryptococcus neoformans-Cryptococcus gattii species complex. Rev Iberoam Micol. 2014;31:188–92.CrossRefPubMed
17.
go back to reference Meyer W, Castañeda A, Jackson S, Huynh M, Castañeda E, IberoAmerican Cryptococcal Study Group. Molecular typing of IberoAmerican Cryptococcus neoformans isolates. Emerg Infect Dis. 2003;9:189–95.CrossRefPubMedPubMedCentral Meyer W, Castañeda A, Jackson S, Huynh M, Castañeda E, IberoAmerican Cryptococcal Study Group. Molecular typing of IberoAmerican Cryptococcus neoformans isolates. Emerg Infect Dis. 2003;9:189–95.CrossRefPubMedPubMedCentral
18.
go back to reference Cattana ME, Tracogna MF, Fernández MS, Carol Rey MC, Sosa MA, Giusiano GE. Genotyping of Cryptococcus neoformans/Cryptococcus gattii complex clinical isolates from Hospital “Dr. Julio C. Perrando”, Resistencia city (Chaco, Argentina). Rev Argent Microbiol. 2013;45:89–92.PubMed Cattana ME, Tracogna MF, Fernández MS, Carol Rey MC, Sosa MA, Giusiano GE. Genotyping of Cryptococcus neoformans/Cryptococcus gattii complex clinical isolates from Hospital “Dr. Julio C. Perrando”, Resistencia city (Chaco, Argentina). Rev Argent Microbiol. 2013;45:89–92.PubMed
19.
go back to reference Cattana ME, Fernández MS, Rojas FD, Sosa M, de LÁ Giusiano G. Genotypes and epidemiology of clinical isolates of Cryptococcus neoformans in Corrientes, Argentina. Rev Argent Microbiol. 2015;47:82–3.PubMed Cattana ME, Fernández MS, Rojas FD, Sosa M, de LÁ Giusiano G. Genotypes and epidemiology of clinical isolates of Cryptococcus neoformans in Corrientes, Argentina. Rev Argent Microbiol. 2015;47:82–3.PubMed
21.
go back to reference Kurtzman CP, Fell JW, Boekhout T. The Yeasts, a Taxonomic Study, 5th ed. Amsterdam: Elsevier, 2011. 2080 Kurtzman CP, Fell JW, Boekhout T. The Yeasts, a Taxonomic Study, 5th ed. Amsterdam: Elsevier, 2011. 2080
22.
go back to reference Meyer W, Marszewska K, Amirmostofian M, Igreja RP, Hardtke C, Methling K, et al. Molecular typing of global isolates of Cryptococcus neoformans var. neoformans by polymerase chain reaction fingerprinting and randomly amplified polymorphic DNA-a pilot study to standardize techniques on which to base a detailed epidemiological survey. Electrophoresis. 1999;20:1790–9.CrossRefPubMed Meyer W, Marszewska K, Amirmostofian M, Igreja RP, Hardtke C, Methling K, et al. Molecular typing of global isolates of Cryptococcus neoformans var. neoformans by polymerase chain reaction fingerprinting and randomly amplified polymorphic DNA-a pilot study to standardize techniques on which to base a detailed epidemiological survey. Electrophoresis. 1999;20:1790–9.CrossRefPubMed
23.
go back to reference Chaturvedi S, Rodeghier B, Fan J, McClelland CM, Wickes BL, Chaturvedi V. Direct PCR of Cryptococcus neoformans MATalpha and MATa pheromones to determine mating type, ploidy, and variety: a tool for epidemiological and molecular pathogenesis studies. J Clin Microbiol. 2000;38:2007–9.PubMedPubMedCentral Chaturvedi S, Rodeghier B, Fan J, McClelland CM, Wickes BL, Chaturvedi V. Direct PCR of Cryptococcus neoformans MATalpha and MATa pheromones to determine mating type, ploidy, and variety: a tool for epidemiological and molecular pathogenesis studies. J Clin Microbiol. 2000;38:2007–9.PubMedPubMedCentral
24.
go back to reference Bava AJ, Robles AM, Negroni R, Arechavala A, Bianchi M. Study of some epidemiological aspects of 253 cases of cryptococcosis. Rev Iberoam Micol. 1997;14:111–4.PubMed Bava AJ, Robles AM, Negroni R, Arechavala A, Bianchi M. Study of some epidemiological aspects of 253 cases of cryptococcosis. Rev Iberoam Micol. 1997;14:111–4.PubMed
25.
go back to reference •• Rajasingham R, Smith RM, Park BJ, Jarvis JN, Govender NP, Chiller TM, et al. Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis. Lancet Infect Dis. 2017;17:873–81. Extensive research that highlights the ongoing burden of HIV-associated cryptococcal disease, primarily in sub-Saharan Africa.CrossRefPubMed •• Rajasingham R, Smith RM, Park BJ, Jarvis JN, Govender NP, Chiller TM, et al. Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis. Lancet Infect Dis. 2017;17:873–81. Extensive research that highlights the ongoing burden of HIV-associated cryptococcal disease, primarily in sub-Saharan Africa.CrossRefPubMed
26.
go back to reference Williamson PR, Jarvis JN, Panackal AA, Fisher MC, Molloy SF, Loyse A, et al. Cryptococcal meningitis: epidemiology, immunology, diagnosis and therapy. Nat Rev Neurol. 2017;13:13–24.CrossRefPubMed Williamson PR, Jarvis JN, Panackal AA, Fisher MC, Molloy SF, Loyse A, et al. Cryptococcal meningitis: epidemiology, immunology, diagnosis and therapy. Nat Rev Neurol. 2017;13:13–24.CrossRefPubMed
Metadata
Title
Contribution of the National Mycology Laboratory Network to Surveillance of Cryptococcosis in Argentina
Authors
Mariana Mazza
Graciela O. Davel
Constanza G. Taverna
Nicolás Refojo
Cristina E. Canteros
Nadia S. Bueno
Guillermina Isla
Ruben A. Abrantes
Alejandra I. Hevia
Adriana I. Toranzo
National Mycology Laboratory Network of Argentina (NMLN)
Publication date
01-12-2017
Publisher
Springer US
Published in
Current Fungal Infection Reports / Issue 4/2017
Print ISSN: 1936-3761
Electronic ISSN: 1936-377X
DOI
https://doi.org/10.1007/s12281-017-0301-x

Other articles of this Issue 4/2017

Current Fungal Infection Reports 4/2017 Go to the issue

Current Management of Fungal Infections (M Miceli, Section Editor)

Clinical Implications of Candida Biofilms

Fungal Infections of Skin and Subcutaneous Tissue (A Bonifaz, Section Editor)

Onychomycosis and Immunodepression

Clinical Mycology Lab Issues (S Córdoba, Section Editor)

Cryptococcus neoformans Epidemiological Cutoff Values