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Journal of Cardiovascular Translational Research

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Open Access 01-06-2019 | Original Article

Comparative Quantification of Arterial Lipid by Intravascular Photoacoustic-Ultrasound Imaging and Near-Infrared Spectroscopy-Intravascular Ultrasound

Authors: Ayeeshik Kole, Yingchun Cao, Jie Hui, Islam A. Bolad, Mouhamad Alloosh, Ji-Xin Cheng, Michael Sturek

Published in: Journal of Cardiovascular Translational Research | Issue 3/2019

Abstract

Intravascular photoacoustic-ultrasound (IVPA-US) imaging and near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) are two hybrid modalities that detect arterial lipid, with comparison necessary to understand the relative advantages of each. We performed in vivo and ex vivo IVPA-US imaging of the iliac arteries of Ossabaw swine with metabolic syndrome (MetS) and lean swine to investigate sensitivity for early-stage atherosclerosis. We repeated imaging ex vivo with NIRS-IVUS for comparison to IVPA-US and histology. Both modalities showed significantly greater lipid in MetS vs. lean swine, but only IVPA-US localized the lipid as perivascular. To investigate late-stage atherosclerosis, we performed ex vivo IVPA-US imaging of a human coronary artery with comparison to NIRS-IVUS and histology. Two advanced fibroatheromas were identified, with agreement between IVPA-measured lipid area and NIRS-derived lipid content. As confirmed histologically, IVPA-US has sensitivity to detect lipid content similar to NIRS-IVUS and provides additional depth resolution, enabling quantification and localization of lipid cores within plaques.

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Title: Comparative Quantification of Arterial Lipid by Intravascular Photoacoustic-Ultrasound Imaging and Near-Infrared Spectroscopy-Intravascular Ultrasound
Authors: Ayeeshik Kole
Yingchun Cao
Jie Hui
Islam A. Bolad
Mouhamad Alloosh
Ji-Xin Cheng
Michael Sturek
Publication date: 01-06-2019
Publisher: Springer US
Published in: Journal of Cardiovascular Translational Research / Issue 3/2019
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-018-9849-2

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