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Journal of Cardiovascular Translational Research

Published in:

01-12-2017 | Original Article

In Vitro Mechanical Property Evaluation of Chitosan-Based Hydrogels Intended for Vascular Graft Development

Authors: Audrey Aussel, Alexandra Montembault, Sébastien Malaise, Marie Pierre Foulc, William Faure, Sandro Cornet, Rachida Aid, Marc Chaouat, Thierry Delair, Didier Letourneur, Laurent David, Laurence Bordenave

Published in: Journal of Cardiovascular Translational Research | Issue 5-6/2017

Abstract

Vascular grafts made of synthetic polymers perform poorly in cardiac and peripheral bypass applications. In these applications, chitosan-based materials can be produced and shaped to provide a novel scaffold for vascular tissue engineering. The goal of this study was to evaluate in vitro the mechanical properties of a novel chitosan formulation to assess its potential for this scaffold. Two chitosan-based hydrogel tubes were produced by modulating chitosan concentration. Based on the standard ISO 7198:1998, the hydrogel tubes were characterized in vitro in terms of suture retention strength, tensile strength, compliance, and burst pressure. By increasing chitosan concentration, suture retention value increased to reach 1.1 N; average burst strength and elastic moduli also increased significantly. The compliance seemed to exhibit a low value for chitosan tubes of high concentration. By modulating chitosan concentration, we produced scaffolds with suitable mechanical properties to be implanted in vivo and withstand physiological blood pressures.

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Title: In Vitro Mechanical Property Evaluation of Chitosan-Based Hydrogels Intended for Vascular Graft Development
Authors: Audrey Aussel
Alexandra Montembault
Sébastien Malaise
Marie Pierre Foulc
William Faure
Sandro Cornet
Rachida Aid
Marc Chaouat
Thierry Delair
Didier Letourneur
Laurent David
Laurence Bordenave
Publication date: 01-12-2017
Publisher: Springer US
Published in: Journal of Cardiovascular Translational Research / Issue 5-6/2017
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-017-9763-z

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