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Journal of Cardiovascular Translational Research

Published in:

01-08-2016 | Original Article

A Multidisciplinary Assessment of Remote Myocardial Fibrosis After Reperfused Myocardial Infarction in Swine and Patients

Authors: Arantxa Hervas, Amparo Ruiz-Sauri, Jose Gavara, Jose V. Monmeneu, Elena de Dios, Cesar Rios-Navarro, Nerea Perez-Sole, Itziar Perez, Daniel Monleon, Jose M. Morales, Gema Minana, Julio Nunez, Clara Bonanad, Ana Diaz, Jose M. Vila, Francisco J. Chorro, Vicente Bodi

Published in: Journal of Cardiovascular Translational Research | Issue 4/2016

Abstract

In extensive nonreperfused myocardial infarction (MI), remote fibrosis has been documented. Early reperfusion by primary angioplasty represents the gold standard method to minimize the extension of the infarction. We aimed to ascertain whether fibrosis also affects remote regions in reperfused MI in swine and patients. Swine were subjected to a transient occlusion of the left anterior descending artery followed by 1-week or 1-month reperfusion. Collagen content in the remote area macroscopically, microscopically, by magnetic resonance microimaging, and at the molecular level was similar to controls. In patients with previous MI, samples from autopsies displayed a significant increase in collagen content only in the infarct region. In patients with previous MI submitted to cardiac magnetic resonance-T1 mapping, the extracellular volume fraction in remote segments was similar to that for controls. In all scenarios, the remote region did not show a significant increase of collagen content in comparison with controls.

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Title: A Multidisciplinary Assessment of Remote Myocardial Fibrosis After Reperfused Myocardial Infarction in Swine and Patients
Authors: Arantxa Hervas
Amparo Ruiz-Sauri
Jose Gavara
Jose V. Monmeneu
Elena de Dios
Cesar Rios-Navarro
Nerea Perez-Sole
Itziar Perez
Daniel Monleon
Jose M. Morales
Gema Minana
Julio Nunez
Clara Bonanad
Ana Diaz
Jose M. Vila
Francisco J. Chorro
Vicente Bodi
Publication date: 01-08-2016
Publisher: Springer US
Published in: Journal of Cardiovascular Translational Research / Issue 4/2016
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-016-9698-9

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