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Journal of Cardiovascular Translational Research

Published in:

Open Access 01-10-2012

Myocardial Regenerative Properties of Macrophage Populations and Stem Cells

Authors: Maria Paola Santini, Nadia Rosenthal

Published in: Journal of Cardiovascular Translational Research | Issue 5/2012

Abstract

The capacity to regenerate damaged tissue and appendages is lost to some extent in higher vertebrates such as mammals, which form a scar tissue at the expenses of tissue reconstitution and functionality. Whereas this process can protect from further damage and elicit fast healing, it can lead to functional deterioration in organs such as the heart. Based on the analyses performed in the last years, stem cell therapies may not be sufficient to induce cardiac regeneration and additional approaches are required to overcome scar formation. Among these, the immune cells and their humoral response have become a key parameter in regenerative processes. In this review, we will describe the recent findings on the possible therapeutical use of progenitor and immune cells to rescue a damaged heart.

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Title: Myocardial Regenerative Properties of Macrophage Populations and Stem Cells
Authors: Maria Paola Santini
Nadia Rosenthal
Publication date: 01-10-2012
Publisher: Springer US
Published in: Journal of Cardiovascular Translational Research / Issue 5/2012
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-012-9383-6

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Optimizing Cardiac Repair and Regeneration Through Activation of the Endogenous Cardiac Stem Cell Compartment

Epicardial Progenitor Cells in Cardiac Development and Regeneration

The Hypoxic Epicardial and Subepicardial Microenvironment

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

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