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Published in: Journal of Cardiovascular Translational Research 4/2012

01-08-2012

Cardiovascular Disease Risk in Young People with Type 1 Diabetes

Authors: Janet K. Snell-Bergeon, Kristen Nadeau

Published in: Journal of Cardiovascular Translational Research | Issue 4/2012

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Abstract

Cardiovascular disease (CVD) is the most frequent cause of death in people with type 1 diabetes (T1D), despite modern advances in glycemic control and CVD risk factor modification. CVD risk identification is essential in this high-risk population, yet remains poorly understood. This review discusses the risk factors for CVD in young people with T1D, including hyperglycemia, traditional CVD risk factors (dyslipidemia, smoking, physical activity, hypertension), as well as novel risk factors such as insulin resistance, inflammation, and hypoglycemia. We present evidence that adverse changes in cardiovascular function, arterial compliance, and atherosclerosis are present even during adolescence in people with T1D, highlighting the need for earlier intervention. The methods for investigating cardiovascular risk are discussed and reviewed. Finally, we discuss the observational studies and clinical trials which have thus far attempted to elucidate the best targets for early intervention in order to reduce the burden of CVD in people with T1D.
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Metadata
Title
Cardiovascular Disease Risk in Young People with Type 1 Diabetes
Authors
Janet K. Snell-Bergeon
Kristen Nadeau
Publication date
01-08-2012
Publisher
Springer US
Published in
Journal of Cardiovascular Translational Research / Issue 4/2012
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI
https://doi.org/10.1007/s12265-012-9363-x

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