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Journal of Cardiovascular Translational Research
Published in: Journal of Cardiovascular Translational Research 2/2012

Open Access 01-04-2012

Mathematical Modeling and Simulation of Ventricular Activation Sequences: Implications for Cardiac Resynchronization Therapy

Author: Mark Potse

Published in: Journal of Cardiovascular Translational Research | Issue 2/2012

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Abstract

Next to clinical and experimental research, mathematical modeling plays a crucial role in medicine. Biomedical research takes place on many different levels, from molecules to the whole organism. Due to the complexity of biological systems, the interactions between components are often difficult or impossible to understand without the help of mathematical models. Mathematical models of cardiac electrophysiology have made a tremendous progress since the first numerical ECG simulations in the 1960s. This paper briefly reviews the development of this field and discusses some example cases where models have helped us forward, emphasizing applications that are relevant for the study of heart failure and cardiac resynchronization therapy.
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Metadata
Title
Mathematical Modeling and Simulation of Ventricular Activation Sequences: Implications for Cardiac Resynchronization Therapy
Author
Mark Potse
Publication date
01-04-2012
Publisher
Springer US
Published in
Journal of Cardiovascular Translational Research / Issue 2/2012
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI
https://doi.org/10.1007/s12265-011-9343-6

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