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Journal of Cardiovascular Translational Research

Published in:

01-04-2012

Cellular Electrophysiological Abnormalities in Dyssynchronous Hearts and During CRT

Authors: Marc Vanderheyden, Martin Penicka, Jozef Bartunek

Published in: Journal of Cardiovascular Translational Research | Issue 2/2012

Abstract

To date, cardiac resynchronization therapy remains the only treatment that enhances systolic function while improving long-term outcome and survival. Dyssynchronous heart failure is characterized by profound global as well as regional cellular and molecular changes, many of which are not observed in synchronous heart failure. The beneficial effects of CRT on myofilament function, G protein-coupled receptor signaling, and adrenergic response are important components for restoring cardiac reserve and reducing arrhythmia, both major limitations in heart failure. Here, we review the molecular alterations associated with dyssynchronous heart failure and their reversibility induced by cardiac resynchronization therapy.

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Title: Cellular Electrophysiological Abnormalities in Dyssynchronous Hearts and During CRT
Authors: Marc Vanderheyden
Martin Penicka
Jozef Bartunek
Publication date: 01-04-2012
Publisher: Springer US
Published in: Journal of Cardiovascular Translational Research / Issue 2/2012
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-011-9335-6

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