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Journal of Cardiovascular Translational Research

Published in:

01-06-2010

MicroRNAs in Cardiac Apoptosis

Author: Peifeng Li

Published in: Journal of Cardiovascular Translational Research | Issue 3/2010

Abstract

MicroRNAs (miRNAs) are small and highly conserved non-coding RNA molecules that function to regulate gene expression. They play important roles in regulating cardiac physiological and pathological events such as hypertrophy, apoptosis, and heart failure. Induction of apoptosis in cardiomyocytes cannot be compensated by efficient cell proliferation, thereby leading to pathophysiological disorders. The miRNAs involved in cardiac apoptosis may provide a mechanism for the pathogenesis and treatment of heart diseases. This review summarizes the role of miRNAs in regulating cardiac apoptosis. In particular, it discusses the potential therapeutic approaches for apoptosis-related cardiac diseases by modulating miRNAs.

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Title: MicroRNAs in Cardiac Apoptosis
Author: Peifeng Li
Publication date: 01-06-2010
Publisher: Springer US
Published in: Journal of Cardiovascular Translational Research / Issue 3/2010
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-010-9175-9

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