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Journal of Cardiovascular Translational Research

Published in:

01-12-2009

The Left Ventricular Outflow in Hypertrophic Cardiomyopathy: From Structure to Function

Authors: Magdi H. Yacoub, Ismail El-Hamamsy, Karim Said, Gehan Magdi, Fatma Abul Enein, Robert George, Alessandra Rossi, Iacopo Olivotto, Franco Cecchi

Published in: Journal of Cardiovascular Translational Research | Issue 4/2009

Abstract

Left ventricular outflow tract obstruction (LVOTO) is one of the defining features of hypertrophic cardiomyopathy (HCM) and one of the main determinants of prognosis. Although the importance of obstruction was recognized since the original description by Teare and Brock, its exact cause and methods for its relief are still being hotly debated. We believe that a rational approach to solving these issues depends on thorough understanding of the specific structure and functions of the left ventricular outflow tract (LVOT) in health and disease. There is now compelling evidence that the LVOT performs a series of vital sophisticated functions which are mediated by the design characteristics, structure, and biological properties of its component parts and that dysregulation of one or more of these functions results in obstruction and other abnormalities. We here review the integrated functions of the LVOT, its structural and functional relationships, with particular reference to its component parts (the major players) and their role in HCM. This knowledge is essential to evolve tailored restorative techniques for treating HCM.

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Title: The Left Ventricular Outflow in Hypertrophic Cardiomyopathy: From Structure to Function
Authors: Magdi H. Yacoub
Ismail El-Hamamsy
Karim Said
Gehan Magdi
Fatma Abul Enein
Robert George
Alessandra Rossi
Iacopo Olivotto
Franco Cecchi
Publication date: 01-12-2009
Publisher: Springer US
Published in: Journal of Cardiovascular Translational Research / Issue 4/2009
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-009-9153-2

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