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Neuroscience Bulletin
Published in: Neuroscience Bulletin 3/2018

01-06-2018 | Original Article

Dendritic Cell Factor 1-Knockout Results in Visual Deficit Through the GABA System in Mouse Primary Visual Cortex

Authors: Jieyun Shi, Qian Li, Tieqiao Wen

Published in: Neuroscience Bulletin | Issue 3/2018

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Abstract

The visual system plays an important role in our daily life. In this study, we found that loss of dendritic cell factor 1 (DCF1) in the primary visual cortex (V1) caused a sight deficit in mice and induced an abnormal increase in glutamic acid decarboxylase 67, an enzyme that catalyzes the decarboxylation of glutamate to gamma aminobutyric acid and CO2, particularly in layer 5. In vivo electrophysiological recordings confirmed a decrease in delta, theta, and beta oscillation power in DCF1-knockout mice. This study presents a previously unknown function of DCF1 in V1, suggests an unknown contact between DCF1 and GABA systems, and provides insight into the mechanism and treatment of visual deficits.
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Metadata
Title
Dendritic Cell Factor 1-Knockout Results in Visual Deficit Through the GABA System in Mouse Primary Visual Cortex
Authors
Jieyun Shi
Qian Li
Tieqiao Wen
Publication date
01-06-2018
Publisher
Springer Singapore
Published in
Neuroscience Bulletin / Issue 3/2018
Print ISSN: 1673-7067
Electronic ISSN: 1995-8218
DOI
https://doi.org/10.1007/s12264-018-0211-0

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