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Open Access 01-04-2017 | Original Article

Sex Differences in Diagnosis and Clinical Phenotypes of Chinese Children with Autism Spectrum Disorder

Authors: Shihuan Wang, Hongzhu Deng, Cong You, Kaiyun Chen, Jianying Li, Chun Tang, Chaoqun Ceng, Yuanyuan Zou, Xiaobing Zou

Published in: Neuroscience Bulletin | Issue 2/2017

Abstract

The aim of this study was to explore the differences between boys and girls in the diagnosis and clinical phenotypes of autism spectrum disorder (ASD) in China's mainland. Children diagnosed with ASD (n = 1064, 228 females) were retrospectively included in the analysis. All children were assessed using the Autism Diagnostic Interview-Revised (ADI-R) and Autism Diagnostic Observation Schedule (ADOS). The results showed that girls scored significantly higher in ADI-R socio-emotional reciprocity than boys, and also scored lower in ADI-R and ADOS restricted and repetitive behaviors (RRBs). Meanwhile, the proportions of girls who satisfied the diagnostic cut-off scores in the ADI-R RRBs domain were lower than in boys (P < 0.05). Our results indicated that girls with ASD show greater socio-emotional reciprocity than boys. Girls also tended to show fewer RRBs than boys, and the type of RRBs in girls differ from those in boys. The ADI-R was found to be less sensitive in girls, particularly for assessment in the RRBs domain.

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Title: Sex Differences in Diagnosis and Clinical Phenotypes of Chinese Children with Autism Spectrum Disorder
Authors: Shihuan Wang
Hongzhu Deng
Cong You
Kaiyun Chen
Jianying Li
Chun Tang
Chaoqun Ceng
Yuanyuan Zou
Xiaobing Zou
Publication date: 01-04-2017
Publisher: Springer Singapore
Published in: Neuroscience Bulletin / Issue 2/2017
Print ISSN: 1673-7067
Electronic ISSN: 1995-8218
DOI: https://doi.org/10.1007/s12264-017-0102-9

At a glance: The STEP trials

Springer Medicine

Sex Differences in Diagnosis and Clinical Phenotypes of Chinese Children with Autism Spectrum Disorder

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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