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Neuroscience Bulletin
Published in: Neuroscience Bulletin 2/2017

Open Access 01-04-2017 | Review

Non-human Primate Models for Brain Disorders – Towards Genetic Manipulations via Innovative Technology

Authors: Zilong Qiu, Xiao Li

Published in: Neuroscience Bulletin | Issue 2/2017

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Abstract

Modeling brain disorders has always been one of the key tasks in neurobiological studies. A wide range of organisms including worms, fruit flies, zebrafish, and rodents have been used for modeling brain disorders. However, whether complicated neurological and psychiatric symptoms can be faithfully mimicked in animals is still debatable. In this review, we discuss key findings using non-human primates to address the neural mechanisms underlying stress and anxiety behaviors, as well as technical advances for establishing genetically-engineered non-human primate models of autism spectrum disorders and other disorders. Considering the close evolutionary connections and similarity of brain structures between non-human primates and humans, together with the rapid progress in genome-editing technology, non-human primates will be indispensable for pathophysiological studies and exploring potential therapeutic methods for treating brain disorders.
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Metadata
Title
Non-human Primate Models for Brain Disorders – Towards Genetic Manipulations via Innovative Technology
Authors
Zilong Qiu
Xiao Li
Publication date
01-04-2017
Publisher
Springer Singapore
Published in
Neuroscience Bulletin / Issue 2/2017
Print ISSN: 1673-7067
Electronic ISSN: 1995-8218
DOI
https://doi.org/10.1007/s12264-017-0115-4

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