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01-12-2009 | Original Paper

Prognostic Value of Tumor-Related Molecular Expression in Gastric Carcinoma

Authors: Zhong-Sheng Zhao, Yuan-Yu Wang, Zai-Yuan Ye, Hou-Quan Tao

Published in: Pathology & Oncology Research | Issue 4/2009

Abstract

In order to identify reliable molecular markers for prognostic prediction in gastric carcinoma, we evaluated the expression of six molecular markers, namely bFGF, IGF-2, HGF, MMP-9, integrin β3 and uPA in gastric cancer. There was a significant correlation between the expression of these markers and the depth of tumor invasion, vessel invasion, lymph node and distant metastasis, TNM stage and microvessel density. The average survival time and 5-year survival rate of patients with positive expression of molecular markers was higher than those with negative expression. Multivariate analysis showed that abnormal expression of bFGF, MMP-9 and uPA, as well as depth of invasion, lymph node and distant metastasis and TNM stage were independently related to poor prognosis of gastric cancer. MMP-9, bFGF and uPA are potential candidates for development as clinically applicable molecular prognostic markers for gastric carcinoma, and may be effective therapeutic targets for the disease in the future.

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Title: Prognostic Value of Tumor-Related Molecular Expression in Gastric Carcinoma
Authors: Zhong-Sheng Zhao
Yuan-Yu Wang
Zai-Yuan Ye
Hou-Quan Tao
Publication date: 01-12-2009
Publisher: Springer Netherlands
Published in: Pathology & Oncology Research / Issue 4/2009
Print ISSN: 1219-4956
Electronic ISSN: 1532-2807
DOI: https://doi.org/10.1007/s12253-009-9158-9

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