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Environmental Health and Preventive Medicine

Published in:

01-05-2015 | Regular Article

Prenatal maternal blood triglyceride and fatty acid levels in relation to exposure to di(2-ethylhexyl)phthalate: a cross-sectional study

Authors: Xiaofang Jia, Yukiko Harada, Masahiro Tagawa, Hisao Naito, Yumi Hayashi, Husna Yetti, Masashi Kato, Seiko Sasaki, Atsuko Araki, Chihiro Miyashita, Tamiko Ikeno, Reiko Kishi, Tamie Nakajima

Published in: Environmental Health and Preventive Medicine | Issue 3/2015

Abstract

Objectives

The hypolipidemic effects of di(2-ethylhexyl)phthalate (DEHP) exposure in humans have not been investigated. And the influences of maternal prenatal DEHP exposure on birth outcomes are not well-known. We aimed to estimate prenatal DEHP exposure in maternal blood, and evaluate its relationships to maternal blood triglyceride (TG) and fatty acid (FA) levels and to birth outcomes.

Methods

We studied 318 mother–newborn pairs residing in Sapporo, Japan. Blood was taken one time during pregnancy for each mother. Maternal and infant characteristics were obtained from medical records and questionnaire survey. We measured DEHP metabolite, mono(2-ethylhexyl) phthalate (MEHP), along with TG and 9 FAs using maternal blood, and analyzed associations of MEHP level with maternal blood TG/FA levels and infant birth dimensions.

Results

Maternal blood TG and palmitoleic/oleic acid levels were higher, but stearic/docosahexaenoic acids and MEHP were lower during late pregnancy. Maternal blood MEHP levels inversely correlated with TG and palmitic/palmitoleic/oleic/linoleic/α-linolenic acids. After adjustment for confounders, we found that a tenfold increase in blood MEHP levels correlated with a decrease in TG of 25.1 mg/dl [95 % confidence interval (CI) 4.8–45.3 mg/dl], and similar relations in palmitic (β = −581.8; 95 % CI −906.5, −257.0), oleic (β = −304.2; 95 % CI −518.0, −90.5), linoleic (β = −348.6; 95 % CI −510.6, −186.6), and α-linolenic (β = −6.3; 95 % CI −9.5, −3.0) acids. However, we observed no correlations between maternal blood MEHP levels and infant birth weight, length, chest circumference, or head circumference.

Conclusions

Ambient DEHP exposure during pregnancy inversely correlated with maternal blood TG and 4 FA levels, but not birth outcomes.

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Title: Prenatal maternal blood triglyceride and fatty acid levels in relation to exposure to di(2-ethylhexyl)phthalate: a cross-sectional study
Authors: Xiaofang Jia
Yukiko Harada
Masahiro Tagawa
Hisao Naito
Yumi Hayashi
Husna Yetti
Masashi Kato
Seiko Sasaki
Atsuko Araki
Chihiro Miyashita
Tamiko Ikeno
Reiko Kishi
Tamie Nakajima
Publication date: 01-05-2015
Publisher: Springer Japan
Published in: Environmental Health and Preventive Medicine / Issue 3/2015
Print ISSN: 1342-078X
Electronic ISSN: 1347-4715
DOI: https://doi.org/10.1007/s12199-014-0440-4

At a glance: The STEP trials

Springer Medicine

Prenatal maternal blood triglyceride and fatty acid levels in relation to exposure to di(2-ethylhexyl)phthalate: a cross-sectional study

Abstract

Objectives

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

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