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International Journal of Hematology
Published in: International Journal of Hematology 1/2018

01-01-2018 | Progress in Hematology

Iron metabolism and related diseases: an overview

Author: Hideo Harigae

Published in: International Journal of Hematology | Issue 1/2018

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Excerpt

Iron is an essential metal not only for oxygen delivery but also for cellular processes, including ATP production and DNA biosynthesis. Iron is utilized by the semi-closed system and is not actively excreted from the body. This system is advantageous, because it prevents the shortage of this important metal and is not influenced by the environmental status. In this system, the iron supply depends on a narrow gate at the duodenum, and iron accumulates in the organ once it is overloaded. These specificities of iron metabolism lead to the high frequency of iron deficiency anemia (IDA) among young females and secondary hemochromatosis due to blood transfusion. …
Literature
1.
Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306:2090–3.CrossRefPubMed
2.
Hentze MW, Martina U, Muckenthaler MU, Galy B, Camaschella C. Two to tango: regulation of mammalian iron metabolism. Cell. 2010;142:24–38.CrossRefPubMed
Metadata
Title
Iron metabolism and related diseases: an overview
Author
Hideo Harigae
Publication date
01-01-2018
Publisher
Springer Japan
Published in
International Journal of Hematology / Issue 1/2018
Print ISSN: 0925-5710
Electronic ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-017-2384-0

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