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International Journal of Hematology
Published in: International Journal of Hematology 5/2015

01-11-2015 | Case Report

Imatinib-induced gastric antral vascular ectasia in three patients with chronic myeloid leukaemia

Authors: Jeremy Ong, David Yeung, Robin Filshie, Timothy P. Hughes, Harshal Nandurkar

Published in: International Journal of Hematology | Issue 5/2015

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Abstract

Imatinib is generally well tolerated, but gastric antral vascular ectasia (GAVE) remains a rare but significant complication of imatinib therapy. Whilst this complication has been described in other disease settings, only one other case of GAVE has been reported in a chronic myeloid leukaemia (CML) patient receiving imatinib. Herein, we present three CML patients with GAVE complicating imatinib therapy. In all cases, GAVE resolved only with cessation of imatinib. This confirms a causal relationship between GAVE and imatinib. GAVE should be considered as a possible cause of anaemia and upper gastrointestinal bleeding in patients receiving imatinib therapy.
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Metadata
Title
Imatinib-induced gastric antral vascular ectasia in three patients with chronic myeloid leukaemia
Authors
Jeremy Ong
David Yeung
Robin Filshie
Timothy P. Hughes
Harshal Nandurkar
Publication date
01-11-2015
Publisher
Springer Japan
Published in
International Journal of Hematology / Issue 5/2015
Print ISSN: 0925-5710
Electronic ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-015-1824-y

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