Published in:
01-11-2015 | Case Report
Romiplostim for secondary thrombocytopenia following allogeneic stem cell transplantation in children
Authors:
Natalia Maximova, D. Zanon, F. Rovere, A. Maestro, G. Schillani, R. Paparazzo
Published in:
International Journal of Hematology
|
Issue 5/2015
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Abstract
The outcome of romiplostim for secondary failure of platelet recovery (SFPR) was investigated in children who had undergone hematopoietic stem cell transplantation (HSCT). Seven transfusion-dependent pediatric patients (median age 11 years), with platelet counts below 10 × 109/L, received four weekly doses of subcutaneous romiplostim to treat SFPR developed after HSCT. All patients, except one (patient 4), became platelet transfusion-independent in the second week from the beginning of treatment and no patient needed to discontinue drug treatment because of adverse events. Romiplostim could represent a beneficial first-line treatment, but further studies are required.