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International Journal of Hematology
Published in: International Journal of Hematology 5/2015

01-05-2015 | Progress in Hematology

Recent topics in graft-versus-host disease: from the perspectives of pathogenesis and treatment

Author: Makoto Murata

Published in: International Journal of Hematology | Issue 5/2015

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Excerpt

Sustained efforts to conquer graft-versus-host disease (GVHD), a life-threatening complication after allogeneic hematopoietic stem cell transplantation (HSCT), have been made over the years. However, the pathogenesis remains to be completely elucidated, and optimization of prophylaxis and therapy for this condition has thus not yet been accomplished. GVHD occurs in more than half of allogeneic HSCT recipients, and steroid-refractory GVHD carries a particularly poor prognosis. Nonetheless, recent research has provided opportunities to better understand the pathogenesis of GVHD and develop new strategies for prophylaxis and therapy of GVHD. …
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Metadata
Title
Recent topics in graft-versus-host disease: from the perspectives of pathogenesis and treatment
Author
Makoto Murata
Publication date
01-05-2015
Publisher
Springer Japan
Published in
International Journal of Hematology / Issue 5/2015
Print ISSN: 0925-5710
Electronic ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-015-1789-x

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