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International Journal of Hematology
Published in: International Journal of Hematology 5/2015

01-05-2015 | Images in Hematology

Disappearance of double minute chromosomes with MYC amplification in relapsed acute myeloid leukemia after stem cell transplantation

Authors: Katsuya Yamamoto, Kimikazu Yakushijin, Keiji Kurata, Yukinari Sanada, Shinichiro Kawamoto, Hiroshi Matsuoka, Hironobu Minami

Published in: International Journal of Hematology | Issue 5/2015

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Excerpt

Double minute chromosomes (dmin) are small, acentric, extrachromosomal fragments that frequently mediate oncogene amplification and reflect rapid disease progression in human tumors. It has been shown that elimination of dmin can be induced by treating cancer cells with low concentrations of hydroxyurea or gemcitabine in vitro, resulting in reduced tumorigenicity and reversion of phenotype [1, 2]. Morphologically, the loss of dmin is facilitated by incorporation of dmin into micronuclei. However, this phenomenon has been reported only infrequently in primary tumor cells from patients [3]. …
Literature
1.
Von Hoff DD, McGill JR, Forseth BJ, Davidson KK, Bradley TP, Van Devanter DR, et al. Elimination of extrachromosomally amplified MYC genes from human tumor cells reduces their tumorigenicity. Proc Natl Acad Sci USA. 1992;89:8165–9.CrossRef
2.
Yu L, Zhao Y, Quan C, Ji W, Zhu J, Huang Y, et al. Gemcitabine eliminates double minute chromosomes from human ovarian cancer cells. PLoS One. 2013;8:e71988.CrossRefPubMedCentralPubMed
3.
Raymond E, Faivre S, Weiss G, McGill J, Davidson K, Izbicka E, et al. Effects of hydroxyurea on extrachromosomal DNA in patients with advanced ovarian carcinomas. Clin Cancer Res. 2001;7:1171–80.PubMed
4.
Schoenlein PV, Barrett JT, Kulharya A, Dohn MR, Sanchez A, Hou DY, et al. Radiation therapy depletes extrachromosomally amplified drug resistance genes and oncogenes from tumor cells via micronuclear capture of episomes and double minute chromosomes. Int J Radiat Oncol Biol Phys. 2003;55:1051–65.CrossRefPubMed
5.
Yamamoto K, Okamura A, Sanada Y, Yakushijin K, Matsuoka H, Minami H. Micronuclei-associated MYC amplification in the form of double minute chromosomes in acute myeloid leukemia. Am J Hematol. 2013;88:717–8.CrossRefPubMed
6.
Chinen Y, Sakamoto N, Nagoshi H, Taki T, Maegawa S, Tatekawa S, et al. 8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia. J Hematol Oncol. 2014;7:68.CrossRefPubMedCentralPubMed
Metadata
Title
Disappearance of double minute chromosomes with MYC amplification in relapsed acute myeloid leukemia after stem cell transplantation
Authors
Katsuya Yamamoto
Kimikazu Yakushijin
Keiji Kurata
Yukinari Sanada
Shinichiro Kawamoto
Hiroshi Matsuoka
Hironobu Minami
Publication date
01-05-2015
Publisher
Springer Japan
Published in
International Journal of Hematology / Issue 5/2015
Print ISSN: 0925-5710
Electronic ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-015-1757-5

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