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International Journal of Hematology
Published in: International Journal of Hematology 4/2015

01-04-2015 | Progress in Hematology

The RUNX1–PU.1 axis in the control of hematopoiesis

Authors: Maria Rosaria Imperato, Pierre Cauchy, Nadine Obier, Constanze Bonifer

Published in: International Journal of Hematology | Issue 4/2015

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Abstract

The differentiation from multipotent hematopoietic stem cells (HSC) to mature and functional blood cells requires the finely tuned regulation of gene expression at each stage of development. Specific transcription factors play a key role in this process as they modulate the expression of their target genes in an exquisitely lineage-specific manner. A large number of important transcriptional regulators have been identified which establish and maintain specific gene expression patterns during hematopoietic development. Hematopoiesis is therefore a paradigm for investigating how transcription factors function in mammalian cells, thanks also to the evolution of genome-wide and the next-generation sequencing technologies. In this review, we focus on the current knowledge of the biological and functional properties of the hematopoietic master regulator RUNX1 (also known as AML1, CBFA2, PEBP2aB) transcription factor and its main downstream target PU.1. We will outline their relationship in determining the fate of the myeloid lineage during normal stem cell development and under conditions when hematopoietic development is subverted by leukemic transformation.
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Metadata
Title
The RUNX1–PU.1 axis in the control of hematopoiesis
Authors
Maria Rosaria Imperato
Pierre Cauchy
Nadine Obier
Constanze Bonifer
Publication date
01-04-2015
Publisher
Springer Japan
Published in
International Journal of Hematology / Issue 4/2015
Print ISSN: 0925-5710
Electronic ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-015-1762-8

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