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Spi-1 is a putative oncogene in virally induced murine erythroleukaemias

Nature volume 331, pages 277–280 (1988)Cite this article

Abstract

Retroviral insertional mutagenesis has been proposed as an efficient mechanism to turn on or to increase the expression of oncogenes in several avian or mammal models. Integration site studies of avian leukosis virus, murine leukaemia and murine mammary tumour viruses led to the coleutification of highly conserved genes whose expression is induced or increased during leukaemogenesis, probably through enhancer elements present in the retroviral long terminal repeats1–12. This is reminiscent of the activation of cellular proto-oncogenes or putative oncogenes in numerous human tumours and leukaemias as a result of chromosomal translocations or DNA rearrangements. Here we report the characterization of a new putative oncogene isolated from a murine erythroleukaemia induced by the acute leukaemogenic retrovirus spleen focus forming virus (SFFV). An important and unusual feature of this genomic locus Spi-l (for SFFV proviral integration) is that rearrangements due to SFFV integration were found in 95% of the erythroid tumours studied. A 4.0-kilobase messenger RNA was detected in rearranged tumours. NoSpi-l rearrangement was detected in other virally induced myeloid, lymphoid or erythroid tumours tested.

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References

  1. Hayward, W. S., Neel, B. G. & Astrin, S. M. Nature 290, 475–480 (1981).

    Article  ADS  CAS  PubMed  Google Scholar 

  2. Noori-Daloii, M. R., Swift, R. A., Kung, H., Crittenden, L. B. & Witter, R. L. Nature 294, 574–576 (1981).

    Article  ADS  CAS  PubMed  Google Scholar 

  3. Fung, Y. T., Lewis, W. G., Crittenden, L. B. & Kung, H. Cell 33, 357–368 (1983).

    Article  CAS  PubMed  Google Scholar 

  4. Shen-ong, G. L. C., Potter, M., Mushinsky, J. F., Lavu, S. & Reddy, E. P. Science 225, 1077–1080 (1984).

    Article  ADS  Google Scholar 

  5. Nusse, R. & Varmus, H. E. Cell 31, 99–109 (1982).

    Article  CAS  PubMed  Google Scholar 

  6. Peters, G., Brookes, S., Smith, R. & Dickson, C. Cell 33, 369–377 (1983).

    Article  CAS  PubMed  Google Scholar 

  7. Cuypers, T. H. et al. Cell 37, 141–150 (1984).

    Article  CAS  PubMed  Google Scholar 

  8. Tsichlis, P.N., Strauss, P. G. & Lohse, M. E. J. Virol. 56, 258–267 (1985).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Lemay, G. & Jolicoeur, P. Proc. natn. Acad. Sci. U.S.A. 81, 38–42 (1984).

    Article  ADS  CAS  Google Scholar 

  10. Silver, J. & Kozak, C. J. Virol. 57, 526–533 (1986).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Sola, B., Fichelson, S., Bordereaux, D., Tambourin, P. & Gisselbrecht, S. J. Virol. 60, 718–725 (1986).

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Villemur, R., Monczak, Y., Rassart, E., Kozak, C. & Jolicoeur, P. Molec. cell. Biol. 7, 512–522 (1987).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Tambourin, P. E., Wendling, F., Jasmin, C. & Smadja-Joffe, F. Leuk. Res. 3, 117–129 (1979).

    Article  CAS  PubMed  Google Scholar 

  14. Wendling, F., Moreau-Gachelin, F. & Tambourin, P. Proc. natn. Acad. Sci. U.S.A. 78, 3614–3618 (1981).

    Article  ADS  CAS  Google Scholar 

  15. Mager, D., Mak, T. & Bernstein, A. Nature 288, 592–594 (1981).

    Article  ADS  Google Scholar 

  16. Wolff, L. & Ruscetti, S. Science 228, 1549–1552 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  17. Wolff, L., Tambourin, P. & Ruscetti, S. Virology 152, 272–276 (1986).

    Article  CAS  PubMed  Google Scholar 

  18. Linemeyer, D. L., Menke, J. G., Ruscetti, S. K., Evans, L. H. & Scolnick, E. M. J. Virol. 43, 223–233 (1982).

    CAS  PubMed  PubMed Central  Google Scholar 

  19. Mowat, M., Cheng, A., Kimura, N., Bernstein, A. & Benchimol, S. Nature 314, 633–636 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  20. Moreau-Gachelin, F., Robert-Lezenes, J., Mathieu-Mahul, D., Gisselbrecht, S. & Larsen, C. J. Biochimie 65, 259–266 (1983).

    Article  CAS  PubMed  Google Scholar 

  21. Moreau-Gachelin, F. et al. J. Virol. 57, 349–352 (1986).

    CAS  PubMed  PubMed Central  Google Scholar 

  22. Moreau-Gachelin, F., Robert-Lezenes, J., Wendling, F., Tavitian, A. & Tambourin, P. J. Virol. 53, 292–295 (1985).

    CAS  PubMed  PubMed Central  Google Scholar 

  23. Karn, J., Brenner, S., Barnett, L. & Cesarini, G. Proc. natn. Acad. Sci. U.S.A. 77, 5172–5176 (1980).

    Article  ADS  CAS  Google Scholar 

  24. Linemeyer, D. L., Ruscetti, S. K., Menke, J. G. & Scolnick, E. M. J. Virol. 35, 710–721 (1980).

    CAS  PubMed  PubMed Central  Google Scholar 

  25. Chow, V., Ben-David, Y., Bernstein, A., Benchimol, S. & Mowat, M. J. Virol. 61, 2777–2781 (1987).

    CAS  PubMed  PubMed Central  Google Scholar 

  26. Robert-Lezenes, J., Moreau-Gachelin, F., Meneceur, P. & Tambourin P. Leuk, Res. 8, 975–984 (1984).

    Article  CAS  Google Scholar 

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Author notes

  1. Françoise Moreau-Gachelin: To whom correspondence should be addressed.

Authors and Affiliations

  1. INSERM U-248, Faculté de Médecine Lariboisière-Saint Louis, 10 avenue de Verdun, 75010, Paris, France

    Françoise Moreau-Gachelin & Armand Tavitian

  2. INSERM U-152 Hôpital Cochin, 27, rue du Fbg Saint Jacques, 75014, Paris, France

    Pierre Tambourin

Authors
  1. Françoise Moreau-Gachelin
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  2. Armand Tavitian
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  3. Pierre Tambourin
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Moreau-Gachelin, F., Tavitian, A. & Tambourin, P. Spi-1 is a putative oncogene in virally induced murine erythroleukaemias. Nature 331, 277–280 (1988). https://doi.org/10.1038/331277a0

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