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01-05-2015 | Original Article

Study of correlation between state and composition of lipid phase and change in erythrocytes structure under induction of oxidative processes

Authors: Viktor V. Revin, Svetlana M. Filatova, Ilya V. Syusin, Marina Yu. Yazykova, Elvira S. Revina, Natalia V. Gromova, Arkadiy A. Devyatkin

Published in: International Journal of Hematology | Issue 5/2015

Abstract

We investigated human blood erythrocytes under oxidative stress in vitro and established a correlation between composition and state of lipids and changes in erythrocytes structure under induced oxidative stress. These changes may serve as an indicator of not only the erythrocyte state but of systemic processes that occur at the level of the whole organism, including various pathologies as well. We found that a pyrimidine derivative xymedon used in the present study is an effective inhibitor of oxidative processes. Xymedon may be useful as an antioxidant for preserving the structural and functional characteristics of the erythrocytes in the treatment of organisms exposed to physical and toxic factors causing oxidative stress.

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Title: Study of correlation between state and composition of lipid phase and change in erythrocytes structure under induction of oxidative processes
Authors: Viktor V. Revin
Svetlana M. Filatova
Ilya V. Syusin
Marina Yu. Yazykova
Elvira S. Revina
Natalia V. Gromova
Arkadiy A. Devyatkin
Publication date: 01-05-2015
Publisher: Springer Japan
Published in: International Journal of Hematology / Issue 5/2015
Print ISSN: 0925-5710
Electronic ISSN: 1865-3774
DOI: https://doi.org/10.1007/s12185-015-1758-4

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