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International Journal of Hematology
Published in: International Journal of Hematology 5/2013

01-05-2013 | Case Report

Interdigitating dendritic cell sarcoma presenting simultaneously with acute myelomonocytic leukemia: report of a rare case and literature review

Authors: Yi-Zhi Jiang, Ning-Zheng Dong, De-Pei Wu, Sheng-Li Xue

Published in: International Journal of Hematology | Issue 5/2013

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Abstract

Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare tumor derived from interdigitating dendritic cells. We report the first case of a 64-year-old Chinese woman who was diagnosed with simultaneous IDCS and acute myelomonocytic leukemia (AML-M4). The patient had undergone chemotherapy for breast cancer 6 years previously. Based on the laboratory results, both the IDCS and the AML-M4 in this patient were determined to be of myelogenous origination. Furthermore, a review of 62 IDCS cases (Medline database, key word: IDCS) reported to date revealed that as many as 17 % of the patients had malignant disease and received radiotherapy and/or chemotherapy prior to developing IDCS, and that this group of patients showed worse prognosis compared with counterparts. The patient in the present report showed poor response to four cycles of sequential chemotherapy, and died 6 months after the initial diagnosis.
Literature
1.
Swerdlow SH, Campo E, Harris NL, et al. Histiocytic sarcoma. In: Grogan TM, Pileri SA, Chan JKC, et al., editors. WHO classification of tumors of haematopoietic and lymphoid tissues. 4th ed. Lyon: IARC Press; 2008. p. 354–55.
2.
Pileri SA, Grogan TM, Harris NL, Banks P, Campo E, Chan JK, et al. Tumours of histiocytes and dendritic cell: all immunohistochemical approach to classification from the international lymphoma study group based on 61 cases. Histopathology. 2002;41:1–29.PubMedCrossRef
3.
Barwell N, Howatson R, Jackson A, Johnson A, Jarrett RF, Cook G. Interdigitating dendritic cell sarcoma of salivary gland associated lymphoid not associated with HHV28 or EBV infection. J Clin Pathol. 2004;57:87–9.PubMedCrossRef
4.
De Pas T, Spitaleri G, Pruneri G, Curigliano G, Noberasco C, Luini A, et al. Dendritic cell sarcoma: an analytic overview of the literature and presentation of original five cases. Crit Rev Oncol Hematol. 2008;65:1–7.PubMedCrossRef
5.
Olnes MJ, Nicol T, Duncan M, Bohlman M, Erlich R. Interdigitating dendritic cell sarcoma: a rare malignancy responsive to ABVD chemotherapy. Leuk Lymphoma. 2002;43:817–21.PubMedCrossRef
6.
Traweek ST, Arber DA, Rappaport H, Brynes RK. Extramedullary myeloid cell tumors. An immunohistochemical and morphologic study of 28 cases. Am J Surg Pathol. 1993;17:1011–9.PubMedCrossRef
7.
Vermi W, Facchetti F, Rosati S, Rossi E, Festa S, Remotti D, et al. Nodal and extranodal tumor-forming accumulation of plasmacytoid monocytes/interferon-producing cells associated with myeloid disorders. Am J Surg Pathol. 2004;28:585–95.PubMedCrossRef
8.
Benet C, Gomez A, Aquilar C, Delattre C, Verqier B, Beylot-Barry M, et al. Histologic and immunohistologic characterization of skin localization of myeloid disorders. Am J Clin Pathol. 2011;135:278–90.PubMedCrossRef
9.
Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. World Health Organization classification of tumors. Pathology and genetics of tumors of haematopoietic and lymphoid tissues. Lyon: IARC Press; 2001. p. 273–89.
10.
Fonseca R, Yamakawa M, Nakamura S, van Heerde P, Miettinen M, Shek TW, et al. Follicular dendritic cell sarcoma and interdigitating reticulum cell sarcoma: a review. Am J Hematol. 1998;59:161–7.PubMedCrossRef
11.
Gaertner EM, Tsokos M, Derringer GA, Neuhauser TS, Arciero C, Andriko JA. Interdigitating dendritic cell sarcoma. A report of four cases and review of the literature. Am J Clin Pathol. 2001;115:589–97.PubMedCrossRef
12.
Kairouz S, Hashash J, Kabbara W, McHayleh W, Tabbara IA. Dendritic cell neoplasms: an overview. Am J Hematol. 2007;82:924–8.PubMedCrossRef
13.
Cossu A, Deiana A, Lissia A, Dedola MF, Cocco L, Palmieri G, et al. Synchronous interdigitating dendritic cell sarcoma and B-cell small lymphocytic lymphoma in a lymph node. Arch Pathol Lab Med. 2006;130:544–7.PubMed
14.
Feldman AL, Minniti C, Santi M, Downing JR, Raffeld M, Jaffe ES. Histiocytic sarcoma after acute lymphoblastic leukaemia: a common clonal origin. Lancet Oncol. 2004;5:248–50.PubMedCrossRef
15.
Feldman AL, Arber DA, Pittaluga S, Martinez A, Burke JS, Raffeld M, et al. Clonally related follicular lymphomas and histiocytic/dendritic cell sarcoma: evidence for transdifferentiation of the follicular clone. Blood. 2008;111:5433–9.PubMedCrossRef
16.
Martin MG, Welch JS, Luo J, Ellis MJ, Graubert TA, Walter MJ. Therapy related acute myeloid leukemia in breast cancer survivors, a population-based study. Breast Cancer Res Treat. 2009;118:593–8.PubMedCrossRef
17.
Howard RA, Gilbert ES, Chen BE, Hall P, Storm H, Pukkala E, et al. Leukemia following breast cancer: an international population-based study of 376,825 women. Breast Cancer Res Treat. 2007;105:359–68.PubMedCrossRef
18.
19.
Azim HA Jr, de Azambuja E, Colozza M, Bines J, Piccart MJ. Long-term toxic effects of adjuvant chemotherapy in breast cancer. Ann Oncol. 2011;22:1939–47.PubMedCrossRef
20.
21.
22.
Garnache-Ottou F, Chaperot L, Biichle S, Ferrand C, Remy-Martin JP, Deconinck E, et al. Expression of the myeloid-associated marker CD33 is not an exclusive factor for leukemic plasmacytoid dendritic cells. Blood. 2005;105:1256–64.PubMedCrossRef
23.
24.
Feltkamp CA, Van Heerde P, Feltkamp-Vroom TM, Koudstaal J. A malignant tumor arising from interdigitating cells: light microscopical, ultrastructural, immuno- and enzyme-histochemical characteristics. Virchows Arch A Pathol Anat Histopathol. 1981;393:183–92.CrossRef
25.
Turner RR, Wood GS, Beckstead JH, Colby TV, Horning SJ, Warnke RA. Histiocytic malignancies: morphologic, immunologic and enzymatic heterogeneity. Am J Surg Pathol. 1984;8:485–500.PubMedCrossRef
26.
Salisbury JR, Ramsay AD, Isaacson PG. Histiocytic lymphoma: a report of a case with unusual phenotype. J Pathol. 1985;146:99–106.PubMedCrossRef
27.
Daum GS, Liepman M, Woda BA. Dendritic cell phenotype in localized malignant histiocytosis of the small intestine. Arch Pathol Lab Med. 1985;109:647–50.PubMed
28.
Chan WC, Zaatari G. Lymph node interdigitating reticulum cell sarcoma. Am J Clin Pathol. 1986;85:739–44.PubMed
29.
Van den Oord JJ, De Wolf-Peeters C, De Vos R, Thomas J, Desmet VJ. Sarcoma arising from interdigitating reticulum cells: report of a case, studied with light and electron microscopy, and enzyme and immunohistochemistry. Histopathology. 1986;10:509–23.PubMedCrossRef
30.
Hui PK, Feller AC, Kaiserling H, Hesse G, Rodermund OE, Haneke E, et al. Skin tumor of T accessory cells (interdigitating reticulum cells) with high content of T lymphocytes. Am J Dermatopathol. 1987;9:129–37.PubMedCrossRef
31.
Nakamura S, Hara K, Suchi T, Ito M, Ikeda H, Nagahama M, et al. Interdigitating cell sarcoma: a morphologic, immunohistologic and enzyme-histochemical study. Cancer. 1988;61:562–8.PubMedCrossRef
32.
Rabkin MS, Kjeldsberg CR, Hammond ME, Wittwer CT, Nathwani B. Ultrastructural immunohistochemical and DNA content analysis of lymphomas having features of interdigitating reticulum cells. Cancer. 1988;61:1594–601.PubMedCrossRef
33.
Weiss LM, Berry GJ, Dorfman RF, Banks P, Kaiserling E, Curtis J, et al. Spindle cell neoplasms of lymph nodes of probable reticulum cell lineage: true reticulum cell sarcoma? Am J Surg Pathol. 1990;14:405–14.PubMedCrossRef
34.
Hammar SP, Rudolph RH, Bockus DE, Remington FL. Interdigitating reticulum cell sarcoma with unusual features. Ultrastruct Pathol. 1991;15:631–44.PubMedCrossRef
35.
Yamakawa M, Matsuda M, Imai Y, Arai S, Harada K, Sato T. Lymph node interdigitating cell sarcoma: a case report. Am J Clin Pathol. 1992;97:139–46.PubMed
36.
Horschowski N, Guitard AM, Arnoux I, Michel G, Thuret I, George F, et al. Interdigitating cell sarcoma: occurrence during incomplete remission of a lymphoblastic lymphoma. Pathol Biol. 1993;41:225–59.
37.
Miettinen M, Fletcher CD, Lasota J. True histiocytic lymphoma of small intestine: analysis of two S-100 protein-positive cases with features of interdigitating reticulum cell sarcoma. Am J Clin Pathol. 1993;100:285–92.PubMed
38.
Nakamura S, Koshikawa T, Kitoh K, Nakayama A, Yamakawa M, Imai Y, et al. Interdigitating cell sarcoma: a morphologic and immunologic study of lymph node lesions in four cases. Pathol Int. 1994;44:374–86.PubMedCrossRef
39.
Rousselet MC, Francois S, Croue A, Maigre M, Saint-Andre JP, Ifrah N. A lymph node interdigitating reticulum cell sarcoma. Arch Pathol Lab Med. 1994;118:183–8.PubMed
40.
Vasef MA, Zaatari GS, Chan WC, Sun NC, Weiss LM, Brynes RK. Dendritic cell tumors associated with low-grade B-cell malignancies: report of three cases. Am J Clin Pathol. 1995;104:696–701.PubMed
41.
Banner B, Beauchamp ML, Liepman M, Woda BA. Interdigitating reticulum-cell sarcoma of the intestine: a case report and review of the literature. Diagn Cytopathol. 1997;17:216–22.PubMedCrossRef
42.
Andriko JW, Kaldjian EP, Tsokos M, Abbondanzo SL, Jaffe ES. Reticulum cell neoplasms of lymph nodes: a clinicopathologic study of 11 cases with recognition of a new subtype derived from fibroblastic reticular cells. Am J Surg Pathol. 1998;22:1048–58.PubMedCrossRef
43.
Luk IS, Shek TW, Tang VW, Ng WF. Interdigitating dendritic cell tumor of the testis: a novel testicular spindle cell neoplasm. Am J Surg Pathol. 1999;23:1141–8.PubMedCrossRef
44.
Kawachi K, Nakatani Y, Inayama Y, Kawano N, Toda N, Misugi K. Interdigitating dendritic cell sarcoma of the spleen: report of a case with a review of the literature. Am J Surg Pathol. 2002;26:530–7.PubMedCrossRef
45.
Pillay K, Solomon R, Daubenton JD, Sinclair-Smith CC. Interdigitating dendritic cell sarcoma: a report of four paediatric cases and review of the literature. Histopathology. 2004;44:283–91.PubMedCrossRef
46.
Porter DW, Gupte GL, Brown RM, Spray C, English MW, DeVille DeGoyet J, et al. Histiocytic sarcoma with interdigitating dendritic cell differentiation. J Pediatr Hematol Oncol. 2004;26:827–30.PubMed
47.
Rupar G, Beham-Schmid C, Galle G, Zigeuner R, Langner C. Interdigitating dendritic cell sarcoma of urinary bladder mimicking large intravesical calculus. Urology. 2005;66:1109.PubMedCrossRef
48.
Androulaki A, Giaslakiotis K, Lazaris AC. Interdigitating dendritic cell sarcoma/tumour of the tonsil. Br J Haematol. 2005;131:415.PubMedCrossRef
49.
Sharma M, Ahsan F, Ah-See KW, McKean ME, Kain R, Chapman AD. Interdigitating dendritic cell sarcoma of the parotid gland. J Laryngol Otol. 2006;120:244–6.PubMed
50.
Kanaan H, Al-Maghrabi J, Linjawi A, Al-Abbassi A, Dandan A, Haider AR. Interdigitating dendritic cell sarcoma of the duodenum with rapidly fatal course: a case report and review of the literature. Arch Pathol Lab Med. 2006;130:205–8.PubMed
51.
Boldin I, Brix-Grunwald G, Scarpatetti MM, Beham-Schmid C, Klein A. Interdigitating dendritic cell sarcoma of the eyelid with a rapidly fatal course. Arch Ophthalmol. 2008;126:738–40.PubMedCrossRef
52.
Lee JC, Christensen T, O’Hara CJ. Metastatic interdigitating dendritic cell sarcoma masquerading as a skin primary tumor: a case report and review of the literature. Am J Dermatopathol. 2009;31:88–93.PubMedCrossRef
53.
Kapucuoglu N, Percinel S, Ventura T, Lang R, Al-Daraji W, Eusebi V. Dendritic cell sarcomas/tumours of the breast: report of two cases. Virchows Arch. 2009;454:333–9.PubMedCrossRef
54.
Zhou ZY, Sun RC, Yang SD, Liang JB, Rui J, Pan MH. Interdigitating dendritic cell tumor of the lymph node in the right submaxillary region: a case report and review of the literature. Int J Surg Pathol. 2011;19:88–92.PubMedCrossRef
55.
Adam Z, Pour L, Veselý K, Krejci M, Fakan F, Hofstadter F, et al. Interdigitating dendritic cell sarcoma of the leg. Onkologie. 2009;32:364–5.PubMedCrossRef
56.
Efune G, Sumer BD, Sarode VR, Wang HY, Myers LL. Interdigitating dendritic cell sarcoma of the parotid gland: case report and literature review. Am J Otolaryngol. 2009;30:264–8.PubMedCrossRef
57.
Fraser CR, Wang W, Gomez M, Zhang T, Mathew S, Furman RR, et al. Transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma to interdigitating dendritic cell sarcoma: evidence for transdifferentiation of the lymphoma clone. Am J Clin Pathol. 2009;132:928–39.PubMedCrossRef
58.
Yang GC, Besanceney CE, Tam W. Histiocytic sarcoma with interdigitating dendritic cell differentiation: a case report with fine needle aspiration cytology and review of literature. Diagn Cytopathol. 2010;38:351–6.PubMed
59.
Ishihara S, Honda Y, Asato T, Nonaka M, Nakagawa S, Hirashima K, et al. Interdigitating dendritic cell sarcoma of the ileum recurred in multiple lymph nodes and duodenum three years after operation without chemotherapy. Pathol Res Pract. 2010;206:514–8.PubMedCrossRef
60.
Wu Q, Liu C, Lei L, Yan X, Wang B, Liu X, et al. Interdigitating dendritic cell sarcoma involving bone marrow in a liver transplant recipient. Transpl Proc. 2010;42:1963–6.CrossRef
61.
Kim SY, Kang JH, Chun SH, Chang MH, Kim YS, Lee SN, et al. Interdigitating dendritic cell sarcoma of the tonsil. Asia Pac J Clin Oncol. 2010;6:144–8.PubMedCrossRef
62.
Weiss GJ, Alarcon A, Halepota M, Penny RJ, Von Hoff DD. Molecular characterization of interdigitating dendritic cell sarcoma. Rare Tumors. 2010;2:e50.PubMedCrossRef
63.
Liu X, Deng Y, Zhang X, Mukherjee R, Huang W, Zhang G, et al. Interdigitating dendritic cell sarcoma following adult liver transplantation: case report and literature review. Pathol Oncol Res. 2011;17:397–402.PubMedCrossRef
64.
Han HS, Lee OJ, Lim SN, An JY, Lee KM, Choe KH, et al. Extranodal interdigitating dendritic cell sarcoma presenting in the pleura: a case report. J Korean Med Sci. 2011;26:304–7.PubMedCrossRef
65.
Nonaka K, Honda Y, Gushima R, Maki Y, Sakurai K, Iyama K, et al. Narrow-band imaging of interdigitating dendritic cell sarcoma originating in the duodenum. Endoscopy. 2011;43:E113–4.PubMedCrossRef
66.
Zhou J, Zhou W, Bai C, Zhou Y, Wang Y. Interdigitating dendritic cell sarcoma: case report with review of the literature. Onkologie. 2011;34:634–7.PubMedCrossRef
67.
Ye Z, Liu F, Cao Q, Lin H. Interdigitating dendritic cell sarcoma of lymph node mimicking granuloma: a case report and review of the literature. Pol J Pathol. 2011;62:274–7.PubMed
68.
Mahamid A, Alfici R, Troitsa A, Anderman S, Groisman G, Zeina AR. Small intestine perforation due to metastatic uterine cervix interdigitating dendritic cell sarcoma: a rare manifestation of a rare disease. Rare Tumors. 2011;3:e46.PubMedCrossRef
Metadata
Title
Interdigitating dendritic cell sarcoma presenting simultaneously with acute myelomonocytic leukemia: report of a rare case and literature review
Authors
Yi-Zhi Jiang
Ning-Zheng Dong
De-Pei Wu
Sheng-Li Xue
Publication date
01-05-2013
Publisher
Springer Japan
Published in
International Journal of Hematology / Issue 5/2013
Print ISSN: 0925-5710
Electronic ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-013-1336-6

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