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01-03-2009 | Case Report

Dendritic cell sarcomas/tumours of the breast: report of two cases

Authors: Nilgun Kapucuoglu, Sıbel Percinel, Terenzio Ventura, RongGang Lang, Wael Al-Daraji, Vincenzo Eusebi

Published in: Virchows Archiv | Issue 3/2009

Abstract

Extranodal follicular dendritic cell sarcoma/tumours (FDCS/Ts) and interdigitating dendritic cell sarcoma/tumours (IDCS/Ts) are rare neoplasms. We present two cases of FDCS/T and IDCS/T of the breast. The FDCS/T case (case 1) presented in a 31-year-old woman and the IDCS/T case (case 2) in a 67-year-old woman who both showed a firm lump in the left breast. The FDCS/T lesion superficially appeared as an anaplastic carcinoma and the IDCS/T was reminiscent of a spindle cell sarcomatoid carcinoma. Nevertheless both lesions were negative for keratins while case 1 displayed neoplastic cells strongly positive for CD21, vimentin and focally for CD68 and S-100 protein. The tumour cells of case 2 were positive for S-100, CD68 and CD45. In breast, an unusual keratin negative tumour composed predominantly of spindle cells arranged in fascicles, storiform pattern or whorls with a lymphoid rich stroma should raise suspicion for FDCS/Ts or IDCS/Ts. The distinction from malignant tumours with similar features is discussed.

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Title: Dendritic cell sarcomas/tumours of the breast: report of two cases
Authors: Nilgun Kapucuoglu
Sıbel Percinel
Terenzio Ventura
RongGang Lang
Wael Al-Daraji
Vincenzo Eusebi
Publication date: 01-03-2009
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 3/2009
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-009-0729-7

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Dendritic cell sarcomas/tumours of the breast: report of two cases

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