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Annals of Behavioral Medicine
Published in: Annals of Behavioral Medicine 3/2014

01-06-2014 | Original Article

Depression Treatment Enhances Adherence to Antiretroviral Therapy: a Meta-Analysis

Authors: Nancy L. Sin, PhD, M. Robin DiMatteo, PhD

Published in: Annals of Behavioral Medicine | Issue 3/2014

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Abstract

Background

Depression is a risk factor for nonadherence to HIV/AIDS treatment.

Purpose

A meta-analysis was conducted to examine whether treatment of depression and psychological distress improves antiretroviral therapy adherence.

Methods

PubMed and PsycINFO databases were systematically searched for relevant articles. Studies that reported an association between depression treatment (or an intervention with a component addressing mental health) and antiretroviral adherence were included.

Results

Across 29 studies of 12,243 persons living with HIV/AIDS, treatment of depression and psychological distress improved antiretroviral adherence (p < 0.001). The odds of a person adhering were 83 % better if he/she was treated for depression. Greater improvements in adherence were found for samples with lower CD4 counts or more severe depression, for interventions specifically targeting depression (versus addressing mental health as a secondary objective), longer treatments, and observational studies.

Conclusions

These findings support the need for detection and treatment of depression among persons living with HIV/AIDS.
Appendix
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Metadata
Title
Depression Treatment Enhances Adherence to Antiretroviral Therapy: a Meta-Analysis
Authors
Nancy L. Sin, PhD
M. Robin DiMatteo, PhD
Publication date
01-06-2014
Publisher
Springer US
Published in
Annals of Behavioral Medicine / Issue 3/2014
Print ISSN: 0883-6612
Electronic ISSN: 1532-4796
DOI
https://doi.org/10.1007/s12160-013-9559-6

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