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At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
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Annals of Behavioral Medicine
Published in: Annals of Behavioral Medicine 1/2011

01-08-2011 | Original Article

Children with Diabetes Compared to Peers: Depressed? Distressed?

A Meta-Analytic Review

Authors: Kerry A. Reynolds, Ph.D., Vicki S. Helgeson, Ph.D.

Published in: Annals of Behavioral Medicine | Issue 1/2011

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Abstract

Background

It is not clear from the literature whether children with diabetes have more psychological difficulties than their peers.

Purpose

This study aims to use meta-analysis to determine if children with diabetes differ from children without a chronic illness in a variety of domains reflecting psychological well-being.

Method

A meta-analysis was undertaken of 22 studies that compared children with diabetes to a comparison group. Outcomes included depression, anxiety, behavioral problems, and related constructs.

Results

Children with diabetes were more likely than comparison groups to experience a variety of psychological difficulties. However, these effects were small to medium in magnitude and were typically smaller among more recent studies and studies with well-matched comparison groups.

Conclusions

This meta-analysis suggests that children with diabetes are at slightly elevated risk for psychological difficulties. Future work will need to help identify children at the highest risk, and to identify factors associated with resilience.
Footnotes
1
We were initially puzzled that the effect size for clinical depression was larger than the effect size for depressive symptoms. Because all five studies that assessed clinical depression also included assessments of depressive symptoms, we conducted an additional analysis of depressive symptoms, restricting inclusion to those that had also assessed clinical depression. The results of this analysis revealed a larger effect size for depressive symptoms across these five studies (ES = 0.60, p < 0.01).
 
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Metadata
Title
Children with Diabetes Compared to Peers: Depressed? Distressed?
A Meta-Analytic Review
Authors
Kerry A. Reynolds, Ph.D.
Vicki S. Helgeson, Ph.D.
Publication date
01-08-2011
Publisher
Springer-Verlag
Published in
Annals of Behavioral Medicine / Issue 1/2011
Print ISSN: 0883-6612
Electronic ISSN: 1532-4796
DOI
https://doi.org/10.1007/s12160-011-9262-4

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