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01-07-2016 | Original Article

18F-fluoride PET/CT for detection of axial involvement in ankylosing spondylitis: correlation with disease activity

Authors: Luca Idolazzi, Matteo Salgarello, Davide Gatti, Ombretta Viapiana, Elisabetta Vantaggiato, Angelo Fassio, Silvano Adami, Maurizio Rossini

Published in: Annals of Nuclear Medicine | Issue 6/2016

Abstract

Objectives

Aim of the current study was to evaluate the relationships between the findings of 18F-fluoride PET/CT (F-PET/CT) reflecting osteo-proliferative processes and the clinical indexes related to the disease activity. The clinical indexes are Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Ankylosing Spondylitis Disease Activity Score (ASDAS).

Methods

We studied 29 AS patients aged 26–69 years with a wide range of disease activity using F-PET/CT. The number of regions of high bone turnover or osteoarthritis features at the spine and at sacroiliac joints was counted.

Results

The number of F-PET/CT positive sites was significantly higher in patients with severe functional impairment and higher disease activity and it was positively related to both BASDAI (r = 0.336; P = 0.036) and ASDAS (r = 0.408; P = 0.014) while the number of degenerative features (osteoarthritis) was related neither with functional impact nor with disease activity.

Conclusions

With a single examination, F-PET/CT accurately identifies the functional impairment and the clinical involvement of AS. The good correlation we found between the number of F-PET/CT positive sites and disease activity candidates this technique also for follow-up of AS.

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Title: 18F-fluoride PET/CT for detection of axial involvement in ankylosing spondylitis: correlation with disease activity
Authors: Luca Idolazzi
Matteo Salgarello
Davide Gatti
Ombretta Viapiana
Elisabetta Vantaggiato
Angelo Fassio
Silvano Adami
Maurizio Rossini
Publication date: 01-07-2016
Publisher: Springer Japan
Published in: Annals of Nuclear Medicine / Issue 6/2016
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-016-1080-0

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

18F-fluoride PET/CT for detection of axial involvement in ankylosing spondylitis: correlation with disease activity

Abstract

Objectives

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

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