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European Journal of Nuclear Medicine and Molecular Imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging 9/2010

01-08-2010 | Original Article

18F-Fluoride PET/CT for detection of sacroiliitis in ankylosing spondylitis

Authors: Klaus Strobel, Dorothee R. Fischer, Giorgio Tamborrini, Diego Kyburz, Katrin D. M. Stumpe, Rolf G. X. Hesselmann, A. Johayem, Gustav K. von Schulthess, Beat A. Michel, Adrian Ciurea

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 9/2010

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Abstract

Purpose

The aim of this study was to evaluate the performance of 18F-fluoride-PET/CT (PET/CT) for the diagnosis of sacroiliac joint (SIJ) arthritis in patients with active ankylosing spondylitis (AS).

Methods

Included in the study were 15 patients with AS according to the modified New York criteria (AS group) and with active disease and 13 patients with mechanical low back pain (MLBP; control group) who were investigated with whole-body 18F-fluoride PET/CT. The ratio of the uptake in the SIJ and that in the sacrum (SIJ/S) was calculated for every joint.

Results

The mean SIJ/S ratio of 30 quantified joints in the AS group was 1.66 (range 1.10–3.07) with PET/CT, and the mean SIJ/S ratio of 26 quantified joints in the MLBP group was 1.12 (range 0.71–1.52). The area under the receiver operating characteristic curve for SIJ arthritis was 0.84. With plain radiography as a the gold standard and taking an SIJ/S ratio of >1.3 as the threshold, the sensitivity, specificity and accuracy on a per patient basis were 80%, 77% and 79%, respectively. On a per SIJ basis, the greatest sensitivity (94%) was found in grade 3 sacroiliitis (n = 16).

Conclusion

Our results suggest that quantitative 18F-fluoride PET/CT may play a role in the diagnosis of sacroiliitis in active AS and is an alternative to conventional bone scintigraphy in times of molybdenum shortage.
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Metadata
Title
18F-Fluoride PET/CT for detection of sacroiliitis in ankylosing spondylitis
Authors
Klaus Strobel
Dorothee R. Fischer
Giorgio Tamborrini
Diego Kyburz
Katrin D. M. Stumpe
Rolf G. X. Hesselmann
A. Johayem
Gustav K. von Schulthess
Beat A. Michel
Adrian Ciurea
Publication date
01-08-2010
Publisher
Springer-Verlag
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 9/2010
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-010-1464-7

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