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Annals of Nuclear Medicine
Published in: Annals of Nuclear Medicine 4/2014

01-05-2014 | Original Article

First experience with early dynamic 18F-NaF-PET/CT in patients with chronic osteomyelitis

Authors: Martin Freesmeyer, Franz F. Stecker, Jan-Henning Schierz, Gunther O. Hofmann, Thomas Winkens

Published in: Annals of Nuclear Medicine | Issue 4/2014

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Abstract

Objective

This study investigates whether early dynamic positron emission tomography/computed tomography (edPET/CT) using 18F-sodium fluoride-(18F-NaF) is feasible in depicting early phases of radiotracer distribution in patients with chronic osteomyelitis (COM).

Methods

A total of 12 ed18F-NaF-PET/CT examinations were performed on 11 consecutive patients (2 female, 9 male; age 53 ± 12 years) in list mode over 5 min starting with radiopharmaceutical injection before standard late 18F-NaF-PET/CT. Eight consecutive time intervals (frames) were reconstructed for each patient: four 15 s, then four 60 s. Several volumes of interest (VOI) were selected, representing the affected area as well as different reference areas within the bone and soft tissue. Maximum and mean ed standardized uptake values (edSUVmax, edSUVmean, respectively) were calculated in each VOI during each frame to measure early fluoride influx and accumulation. Results were compared between affected and non-affected (contralateral) bones.

Results

Starting in the 31–45 s frame, the affected bone area showed significantly higher edSUVmax and edSUVmean compared to the healthy contralateral region. The affected bone areas also significantly differed from non-affected contralateral regions in conventional late 18F-NaF-PET/CT.

Conclusions

This pilot study suggests that, in patients with COM, ed18F-NaF -PET offers additional information about early radiotracer distribution to standard 18F-NaF -PET/CT, similar to a three-phase bone scan. The results should be validated in larger trials which directly compare ed18F-NaF-PET to a three-phase bone scan.
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Metadata
Title
First experience with early dynamic 18F-NaF-PET/CT in patients with chronic osteomyelitis
Authors
Martin Freesmeyer
Franz F. Stecker
Jan-Henning Schierz
Gunther O. Hofmann
Thomas Winkens
Publication date
01-05-2014
Publisher
Springer Japan
Published in
Annals of Nuclear Medicine / Issue 4/2014
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-014-0810-4

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