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01-05-2014 | Original Article

Prognostic value of ¹⁸F-fluorodeoxyglucose uptake before treatment for pharyngeal cancer

Authors: Hidenori Suzuki, Katsuhiko Kato, Yasushi Fujimoto, Yoshiyuki Itoh, Mariko Hiramatsu, Shinji Naganawa, Yasuhisa Hasegawa, Tsutomu Nakashima

Published in: Annals of Nuclear Medicine | Issue 4/2014

Abstract

Objectives

The purpose of this study was to evaluate an association found between overall survival of patients with pharyngeal squamous cell carcinoma (SCC) and pretreatment [¹⁸F]-2-fluorodeoxyglucose (¹⁸F-FDG) uptake, which are assessed by positron emission tomography combined with computed tomography (PET/CT). Next, we asked whether ¹⁸F-FDG uptake is correlated with overall survival in patients with pharyngeal SCC who underwent radical treatments such as surgery and radiotherapy in the multivariate analysis with adjustments for the clinical stage, primary site and treatment group.

Methods

Forty-nine patients who were newly diagnosed as resectable pharyngeal SCC underwent pretreatment ¹⁸F-FDG-PET/CT. We used the maximum standardized uptake value (SUVmax) as ¹⁸F-FDG uptake. Overall survival rate was calculated by the Kaplan–Meier method. Univariate survival analysis was analyzed by log-rank test, and multivariate survival analysis was performed by a Cox proportional hazards model.

Results

Patients with SUVmax of the primary site ≥8 significantly exhibited shorter overall survival in univariate analysis (p < 0.04). Moreover, SUVmax of the primary site ≥8 was a significant prognostic factor in the multivariate analysis (p < 0.03).

Conclusions

These results suggested that SUVmax of the primary site obtained by pretreatment ¹⁸F-FDG-PET/CT assessment is an important prognostic factor in patients with pharyngeal SCC.

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Title: Prognostic value of 18F-fluorodeoxyglucose uptake before treatment for pharyngeal cancer
Authors: Hidenori Suzuki
Katsuhiko Kato
Yasushi Fujimoto
Yoshiyuki Itoh
Mariko Hiramatsu
Shinji Naganawa
Yasuhisa Hasegawa
Tsutomu Nakashima
Publication date: 01-05-2014
Publisher: Springer Japan
Published in: Annals of Nuclear Medicine / Issue 4/2014
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-014-0817-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Prognostic value of ¹⁸F-fluorodeoxyglucose uptake before treatment for pharyngeal cancer

Abstract

Objectives

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

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