Skip to main content
Top
Published in: Annals of Nuclear Medicine 9/2010

01-11-2010 | Original Article

The management of pyothorax-associated lymphoma using 18F-FDG PET/CT

Authors: Kimiteru Ito, Yoshitaka Shida, Kazuo Kubota, Miyako Morooka, Takashi Aruga, Jun Itami, Hiroshi Matsuda

Published in: Annals of Nuclear Medicine | Issue 9/2010

Login to get access

Abstract

Objective

Pyothorax-associated lymphoma (PAL) is a rare form of lymphoma and its management on 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) combined computed tomography (CT) has not been well reported. The purpose of this study was to evaluate the usefulness of FDG PET/CT in patients with PAL.

Materials and methods

Twenty-four PET/CT images in seven patients (5 men and 2 women) with PAL were studied retrospectively. Five of the 24 PET/CT scans were done for diagnosis and staging, 6 for restaging, 3 for follow-up, and 10 to evaluate the treatment response. PET/CT scan interpretations were performed visually and using the maximum standardized uptake values (SUVmax). Additionally, the efficacy of the enhanced CT findings in pre- and post-treatments was described.

Results

Six of the 7 patients with PAL received radiotherapy, and the efficacy of treatment was observed in their lesions. The percentage decrease of SUVmax in PAL was useful in providing complementary information. Enhanced CT findings showed decreasing enhancement of PAL after treatment; however, in five cases, residual masses were confirmed after treatment.

Conclusion

FDG PET/CT may be an ideal modality for reducing the false-positive interpretation of residual masses occurring after treatment for PAL. The SUVmax provides complementary information for the management of PAL.
Literature
1.
go back to reference Iuchi K, Ichimiya A, Akashi A, Mizuta T, Lee YE, Tada H, et al. Non-Hodgkin’s lymphoma of the pleural cavity developing from long-standing pyothorax. Cancer. 1987;60:1771–5.CrossRefPubMed Iuchi K, Ichimiya A, Akashi A, Mizuta T, Lee YE, Tada H, et al. Non-Hodgkin’s lymphoma of the pleural cavity developing from long-standing pyothorax. Cancer. 1987;60:1771–5.CrossRefPubMed
2.
go back to reference Narimatsu H, Ota Y, Kama M, Takeuchi K, Suzuki R, Matsuo K, et al. Clinicopathological features of pyothorax-associated lymphoma; a retrospective survey involving 98 patients. Ann Oncol. 2007;18:122–8.CrossRefPubMed Narimatsu H, Ota Y, Kama M, Takeuchi K, Suzuki R, Matsuo K, et al. Clinicopathological features of pyothorax-associated lymphoma; a retrospective survey involving 98 patients. Ann Oncol. 2007;18:122–8.CrossRefPubMed
3.
go back to reference Nakatsuka S, Yao M, Hoshida Y, Yamamoto S, Iuchi K, Azusa K. Pyothorax-associated lymphoma: a review of 106 cases. J Clin Oncol. 2002;20:4255–60.CrossRefPubMed Nakatsuka S, Yao M, Hoshida Y, Yamamoto S, Iuchi K, Azusa K. Pyothorax-associated lymphoma: a review of 106 cases. J Clin Oncol. 2002;20:4255–60.CrossRefPubMed
4.
go back to reference Fukayama M, Ibuka T, Hayashi Y, Ooba T, Koike M, Mizutani S. Epstein–Barr virus in pyothorax-associated pleural lymphoma. Am J Pathol. 1993;143:1044–9.PubMed Fukayama M, Ibuka T, Hayashi Y, Ooba T, Koike M, Mizutani S. Epstein–Barr virus in pyothorax-associated pleural lymphoma. Am J Pathol. 1993;143:1044–9.PubMed
5.
go back to reference Sasajima Y, Yamabe H, Kobashi Y, Hirai K, Mori S. High expression of the Epstein–Barr virus latent protein EB nuclear antigen-2 on pyothorax-associated lymphomas. Am J Pathol. 1993;143:1280–5.PubMed Sasajima Y, Yamabe H, Kobashi Y, Hirai K, Mori S. High expression of the Epstein–Barr virus latent protein EB nuclear antigen-2 on pyothorax-associated lymphomas. Am J Pathol. 1993;143:1280–5.PubMed
6.
go back to reference Takakuwa T, Luo WJ, Ham MF, Mizuki M, Iuchi K, Aozasa K. Establishment and characterization of unique cell lines derived from pyothorax-associated lymphoma which develops in long-standing pyothorax and is strongly associated with Epstein–Barr virus infection. Cancer Sci. 2003;94:858–63.CrossRefPubMed Takakuwa T, Luo WJ, Ham MF, Mizuki M, Iuchi K, Aozasa K. Establishment and characterization of unique cell lines derived from pyothorax-associated lymphoma which develops in long-standing pyothorax and is strongly associated with Epstein–Barr virus infection. Cancer Sci. 2003;94:858–63.CrossRefPubMed
7.
go back to reference Takakuwa T, Tresnasari K, Rahadiani N, Miwa H, Daibata M, Aozasa K. Cell origin of pyothorax-associated lymphoma: a lymphoma strongly associated with Epstein–Barr virus infection. Leukemia. 2008;22:620–7.CrossRefPubMed Takakuwa T, Tresnasari K, Rahadiani N, Miwa H, Daibata M, Aozasa K. Cell origin of pyothorax-associated lymphoma: a lymphoma strongly associated with Epstein–Barr virus infection. Leukemia. 2008;22:620–7.CrossRefPubMed
8.
go back to reference Lee HY, Goo JM, Lee HJ, Lee CH, Chun EJ, Im JG. The value of computed tomography for predicting empyema-associated malignancy. J Comput Assist Tomogr. 2006;30:453–9.CrossRefPubMed Lee HY, Goo JM, Lee HJ, Lee CH, Chun EJ, Im JG. The value of computed tomography for predicting empyema-associated malignancy. J Comput Assist Tomogr. 2006;30:453–9.CrossRefPubMed
9.
go back to reference Ueda T, Andreas C, Itami J, Miyakawa K, Fujimoto H, Ito H, et al. Pyothorax-associated lymphoma: imaging findings. AJR Am J Roentgenol. 2010;194:76–84.CrossRefPubMed Ueda T, Andreas C, Itami J, Miyakawa K, Fujimoto H, Ito H, et al. Pyothorax-associated lymphoma: imaging findings. AJR Am J Roentgenol. 2010;194:76–84.CrossRefPubMed
10.
go back to reference Minami M, Kawauchi N, Yoshikawa K, Itai Y, Kokubo T, Iguchi M, et al. Malignancy associated with chronic empyema: radiologic assessment. Radiology. 1991;178:417–23.PubMed Minami M, Kawauchi N, Yoshikawa K, Itai Y, Kokubo T, Iguchi M, et al. Malignancy associated with chronic empyema: radiologic assessment. Radiology. 1991;178:417–23.PubMed
11.
go back to reference Asakura H, Togami T, Mitani M, Takashima H, Yokoe K, Yamamoto Y, et al. Usefulness of FDG-PET imaging for the radiotherapy treatment planning of pyothorax-associated lymphoma. Ann Nucl Med. 2005;19:725–8.CrossRefPubMed Asakura H, Togami T, Mitani M, Takashima H, Yokoe K, Yamamoto Y, et al. Usefulness of FDG-PET imaging for the radiotherapy treatment planning of pyothorax-associated lymphoma. Ann Nucl Med. 2005;19:725–8.CrossRefPubMed
12.
go back to reference Juweid ME, Stroobants S, Hoekstra OS, Mottaghy FM, Dietlein M, Guermazi A, Imaging Subcommittee of International Harmonization Project in Lymphoma, et al. Use of positron emission tomography for response assessment of lymphoma: consensus of the Imaging Subcommittee of International Harmonization Project in Lymphoma. J Clin Oncol. 2007;25:571–8.CrossRefPubMed Juweid ME, Stroobants S, Hoekstra OS, Mottaghy FM, Dietlein M, Guermazi A, Imaging Subcommittee of International Harmonization Project in Lymphoma, et al. Use of positron emission tomography for response assessment of lymphoma: consensus of the Imaging Subcommittee of International Harmonization Project in Lymphoma. J Clin Oncol. 2007;25:571–8.CrossRefPubMed
13.
go back to reference Androulaki A, Drakos E, Hatzianastassiou D, Vgenopoulou S, Gazouli M, Korkolopoulou P, et al. Pyothorax-associated lymphoma (PAL): a western case with marked angiocentricity and review of the literature. Histopathology. 2004;44:69–76.CrossRefPubMed Androulaki A, Drakos E, Hatzianastassiou D, Vgenopoulou S, Gazouli M, Korkolopoulou P, et al. Pyothorax-associated lymphoma (PAL): a western case with marked angiocentricity and review of the literature. Histopathology. 2004;44:69–76.CrossRefPubMed
14.
go back to reference Aruga T, Itami J, Nakajima K, Shibata K, Nojo T, Aruga M, et al. Treatment for pyothorax-associated lymphoma. Radiother Oncol. 2000;56:59–63.CrossRefPubMed Aruga T, Itami J, Nakajima K, Shibata K, Nojo T, Aruga M, et al. Treatment for pyothorax-associated lymphoma. Radiother Oncol. 2000;56:59–63.CrossRefPubMed
15.
go back to reference Suga K, Ishikawa Y, Motoyama K, Fujimura N, Suda H, Matsunaga N. Ga-67-avid non-Hodgkin’s lymphoma arising from chronic nontuberculous pyothorax. Clin Nucl Med. 2001;26:247–8.CrossRefPubMed Suga K, Ishikawa Y, Motoyama K, Fujimura N, Suda H, Matsunaga N. Ga-67-avid non-Hodgkin’s lymphoma arising from chronic nontuberculous pyothorax. Clin Nucl Med. 2001;26:247–8.CrossRefPubMed
16.
go back to reference Oh JK, Ahn MI, Kim CH, Cho KD, Cho DG, Kang CU, et al. The value of F-18 FDG-PET/CT in diagnosis of chronic empyema-associated malignancy. Clin Radiol. 2008;63:1177–80.CrossRefPubMed Oh JK, Ahn MI, Kim CH, Cho KD, Cho DG, Kang CU, et al. The value of F-18 FDG-PET/CT in diagnosis of chronic empyema-associated malignancy. Clin Radiol. 2008;63:1177–80.CrossRefPubMed
17.
go back to reference Kostakoglu L, Goldsmith SJ. Fluorine-18 fluorodeoxyglucose positron emission tomography in the staging and follow-up of lymphoma: is it time to shift gears? Eur J Nucl Med. 2000;27:1564–78.CrossRefPubMed Kostakoglu L, Goldsmith SJ. Fluorine-18 fluorodeoxyglucose positron emission tomography in the staging and follow-up of lymphoma: is it time to shift gears? Eur J Nucl Med. 2000;27:1564–78.CrossRefPubMed
18.
go back to reference Kostakoglu L, Leonard JP, Kuji I, Coleman M, Vallabhajosula S, Goldsmith SJ. Comparison of fluorine-18 fluorodeoxyglucose positron emission tomography and Ga-67 scintigraphy in evaluation of lymphoma. Cancer. 2002;94:879–88.CrossRefPubMed Kostakoglu L, Leonard JP, Kuji I, Coleman M, Vallabhajosula S, Goldsmith SJ. Comparison of fluorine-18 fluorodeoxyglucose positron emission tomography and Ga-67 scintigraphy in evaluation of lymphoma. Cancer. 2002;94:879–88.CrossRefPubMed
Metadata
Title
The management of pyothorax-associated lymphoma using 18F-FDG PET/CT
Authors
Kimiteru Ito
Yoshitaka Shida
Kazuo Kubota
Miyako Morooka
Takashi Aruga
Jun Itami
Hiroshi Matsuda
Publication date
01-11-2010
Publisher
Springer Japan
Published in
Annals of Nuclear Medicine / Issue 9/2010
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-010-0408-4

Other articles of this Issue 9/2010

Annals of Nuclear Medicine 9/2010 Go to the issue