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01-03-2021 | Computed Tomography | Case Reports

Aggressive Intraosseous Myofibroma of the Maxilla: Report of a Rare Case and Literature Review

Authors: John Lennon Silva Cunha, Carla Isabelly Rodrigues-Fernandes, Ciro Dantas Soares, Celeste Sánchez-Romero, Pablo Agustin Vargas, Cleverson Luciano Trento, Bruno Augusto Benevenuto de Andrade, Sílvia Ferreira de Sousa, Ricardo Luiz Cavalcanti de Albuquerque-Júnior

Published in: Head and Neck Pathology | Issue 1/2021

Abstract

Myofibroma (MF) is a benign mesenchymal myofibroblast-derived tumor, which occurs most frequently in children, and rarely affects the maxilla. We reported a case of an aggressive intraosseous lesion found in the maxilla of a 9-year-old female child. Intraorally, the swelling extended from tooth 12 to 16, causing displacement of teeth 13, 14, and 15. Computed tomography revealed a large osteolytic lesion causing thinning and cortical erosion. Microscopically, the lesion showed a proliferation of spindle-shaped cells, with elongated nuclei and eosinophilic cytoplasm, arranged in interlaced fascicles. The immunohistochemical analysis revealed cytoplasmic positivity for α-SMA and HHF-35, and negativity for desmin, laminin, S-100, β-catenin, and CD34. Ki-67 was positive in 8% of tumor cells. The diagnosis was MF. Herein, we describe an additional case of central MF arising in the maxilla, including clinical, imaging, microscopical, and immunohistochemical features, as well as a review of the literature.

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Title: Aggressive Intraosseous Myofibroma of the Maxilla: Report of a Rare Case and Literature Review
Authors: John Lennon Silva Cunha
Carla Isabelly Rodrigues-Fernandes
Ciro Dantas Soares
Celeste Sánchez-Romero
Pablo Agustin Vargas
Cleverson Luciano Trento
Bruno Augusto Benevenuto de Andrade
Sílvia Ferreira de Sousa
Ricardo Luiz Cavalcanti de Albuquerque-Júnior
Publication date: 01-03-2021
Publisher: Springer US
Keywords: Computed Tomography
Computed Tomography
Published in: Head and Neck Pathology / Issue 1/2021
Electronic ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-020-01162-y

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Aggressive Intraosseous Myofibroma of the Maxilla: Report of a Rare Case and Literature Review

Abstract

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