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01-12-2020 | Leukoplakia | Original Paper

Benign Alveolar Ridge Keratosis: Clinical and Histopathologic Analysis of 167 Cases

Authors: Asma Almazyad, Chia-Cheng Li, Sook-Bin Woo

Published in: Head and Neck Pathology | Issue 4/2020

Abstract

Benign alveolar ridge keratosis (BARK), the intraoral counterpart of cutaneous lichen simplex chronicus, is a reactive hyperkeratosis caused by trauma or friction that presents as a poorly demarcated white papule or plaque on the keratinized mucosa of the retromolar pad or alveolar ridge mucosa (often edentulous). This is a clinical and histopathologic analysis of BARK including evaluation of p53 expression in selected cases. One hundred and sixty-seven cases of BARK were identified from 2016 to 2017 and 112 (67.1%) occurred in males with a median age of 56 years (range 15–86). The retromolar pad was affected in 107 (64.1%) cases and the edentulous alveolar mucosa in 60 (35.9%) cases, with 17.4% of the cases presenting bilaterally. BARK showed hyperkeratosis often with wedge-shaped hypergranulosis and occasional focal parakeratosis. The epithelium exhibited acanthosis and surface corrugation with tapered rete ridges often interconnected at the tips. The study for p53 performed in 12 cases showed less than 25% nuclear positivity. BARK is a distinct benign clinicopathologic entity caused by friction, which should be clearly distinguished from true leukoplakia, a potentially malignant disorder.

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Title: Benign Alveolar Ridge Keratosis: Clinical and Histopathologic Analysis of 167 Cases
Authors: Asma Almazyad
Chia-Cheng Li
Sook-Bin Woo
Publication date: 01-12-2020
Publisher: Springer US
Keywords: Leukoplakia
Lichen Simplex Chronicus
Leukoplakia
Published in: Head and Neck Pathology / Issue 4/2020
Electronic ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-020-01151-1

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Benign Alveolar Ridge Keratosis: Clinical and Histopathologic Analysis of 167 Cases

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