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01-09-2019 | Leukoplakia | Proceeding of the North American Society of Head and Neck Pathology Companion Meeting, March 17, 2019, National Harbor, MD

Oral Epithelial Dysplasia and Premalignancy

Author: Sook-Bin Woo

Published in: Head and Neck Pathology | Issue 3/2019

Abstract

Leukoplakia and erythroplakia are two entities under the moniker of “oral potentially malignant disorders” that are highly associated with the presence of oral epithelial dysplasia (OED) at first biopsy, while lesions of submucous fibrosis develop OED after being present for years. Importantly, traumatic/frictional keratoses are often mistaken clinically for leukoplakia and it is important for the pathologist to recognize and report them as such. The features of OED have been well-described and other architectural features will be discussed here, in particular verrucous and papillary architecture, bulky epithelial proliferation and epithelial atrophy. Proliferative leukoplakia, verrucous or otherwise, often show only hyperkeratosis in early lesions, with development of OED occurring over time, and squamous cell carcinoma developing in the majority of cases over time. The concept of hyperkeratosis without features of OED and that is not reactive, is likely a precursor to the dysplastic phenotype. Many cases of leukoplakia exhibiting OED are associated with a band of lymphocytes at the interface and these should not be mistaken for oral lichen planus.

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Title: Oral Epithelial Dysplasia and Premalignancy
Author: Sook-Bin Woo
Publication date: 01-09-2019
Publisher: Springer US
Keywords: Leukoplakia
Lichen Planus
Leukoplakia
Published in: Head and Neck Pathology / Issue 3/2019
Electronic ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-019-01020-6

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