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01-12-2019 | Case Report

Malignant Transformation of a Desmoplastic Ameloblastoma to Squamous Cell Carcinoma: A Case Report

Authors: Rehan Rais, Samir K. El-Mofty

Published in: Head and Neck Pathology | Issue 4/2019

Abstract

Ameloblastomas are the most common odontogenic tumors, excluding odontomas. Several morphologic variants have been described including follicular, plexiform, acanthomatous, granular cell, basaloid and desmoplastic. Desmoplastic ameloblastoma differs from other conventional ameloblastomas microscopically, clinically, and radiographically. Ameloblastic carcinoma, the malignant counterpart of ameloblastoma is characterized by cytologic features of malignancy combined within the overall histologic features of conventional ameloblastoma. Malignant transformation of ameloblastoma to squamous cell carcinoma is a controversial subject. Here we report a case of a desmoplastic ameloblastoma with malignant transformation to squamous cell carcinoma in a 49 year old African American man. The patient underwent tumor resection and radiation therapy with no evidence of disease recurrence or progression 16 months post operatively. To our knowledge malignant transformation of a desmoplastic ameloblastoma to squamous cell carcinoma has not so far been reported. This observation may lend some support to the argument that desmoplastic ameloblastoma is phenotypically and biologically distinct entity.

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Title: Malignant Transformation of a Desmoplastic Ameloblastoma to Squamous Cell Carcinoma: A Case Report
Authors: Rehan Rais
Samir K. El-Mofty
Publication date: 01-12-2019
Publisher: Springer US
Published in: Head and Neck Pathology / Issue 4/2019
Electronic ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-018-0946-y

At a glance: The STEP trials

Springer Medicine

Malignant Transformation of a Desmoplastic Ameloblastoma to Squamous Cell Carcinoma: A Case Report

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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