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Head and Neck Pathology
Published in: Head and Neck Pathology 3/2016

01-09-2016 | Original Paper

Detection of Helicobacter pylori in Nasal Polyps

Authors: Divya Bansal, Sonal Sharma, Sarla Agarwal, Rumpa Saha, Neelima Gupta

Published in: Head and Neck Pathology | Issue 3/2016

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Abstract

To detect the presence of Helicobacter pylori in nasal polyps. A case–control study was conducted enrolling 35 patients with nasal polyps (cases) and patients undergoing septoplasty (controls). Fresh tissue samples were used for urea broth test and imprint cytology, while formalin fixed tissue sections were used for morphology, special stains and immunohistochemistry for H. pylori. Fresh stool samples from both groups were tested to correlate the gastrointestinal status. H. pylori was detected in 40.0 % (14/35) of cases and 8.5 % of controls (3/35) (p = 0.004) by immunohistochemistry. Amongst cases, eight were positive with urea broth test, six with imprint cytology (Giemsa stain), three with H & E, and nine with modified McMullen’s stain. Hyperplasia of the lining epithelium and lymphoid aggregates were significantly noticed in nasal polyps positive for H. pylori. Stool antigen test was positive in subjects who were positive for H. pylori in the nasal mucosa. There appears to be an association between H. pylori and nasal polyps. Immunohistochemistry is more sensitive and specific method to detect H. pylori. H. pylori induced inflammatory tissue reaction pattern indicates a possible causal association. Further studies are needed to prove the causal relationship between H. pylori and nasal polyps.
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Metadata
Title
Detection of Helicobacter pylori in Nasal Polyps
Authors
Divya Bansal
Sonal Sharma
Sarla Agarwal
Rumpa Saha
Neelima Gupta
Publication date
01-09-2016
Publisher
Springer US
Published in
Head and Neck Pathology / Issue 3/2016
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-016-0699-4

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