Abstract
The aim of this study was to identify the presence of Helicobacter pylori in nasal polyp specimens of patients with nasal polyposis. A cross-sectional study with control group was performed on fresh tissue samples from 25 patients with nasal polyps, and 25 persons with concha bollusa (control group). Patients with symptoms of gastroesophageal reflux (GERD) were not enrolled. Samples were studied by three methods: polymerase chain reaction (PCR), culture, and urease test. All the diagnostic tests were negative for H. pylori in both the case and control groups. In conclusion, there was no association between H. pylori and nasal polyposis in patients without GERD signs or symptoms in our study, and further studies are needed to assess other potential factors that may influence the development of nasal polyposis.
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Acknowledgments
Special thanks to Farshid Saadat, PhD, who aided in performing PCR procedures, to Maryam Shakiba (M.Sc.) who analyzed the data, and to Mohammad Aghajanpoor and Michael Faryad Jalili, who reviewed the manuscript. Finally, thanks to the Research Office of GUMS which supported the project financially. All the financial and material support for this research was provided by Research Office of Guilan University of Medical Sciences.
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Nemati, S., Mojtahedi, A., Naghavi, S.E. et al. Investigating Helicobacter pylori in nasal polyposis using polymerase chain reaction, urease test and culture. Eur Arch Otorhinolaryngol 269, 1457–1461 (2012). https://doi.org/10.1007/s00405-011-1848-8
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DOI: https://doi.org/10.1007/s00405-011-1848-8