Skip to main content
Top
Published in: Head and Neck Pathology 1/2016

Open Access 01-03-2016 | Special Issue: Sinonasal Tract Pathology. Guest Editors: Justin Bishop, MD and Alessandro Franchi, MD

Non-infectious Inflammatory Lesions of the Sinonasal Tract

Author: Timothy R. Helliwell

Published in: Head and Neck Pathology | Issue 1/2016

Login to get access

Abstract

This review covers the histopathology and pathogenesis of non-infectious inflammatory diseases of the sinonasal tract, in particular, sarcoidosis, granulomatous vasculitides Wegener, Churg–Strauss), relapsing polychondritis, eosinophilic angiocentric fibrosis, chronic rhinosinusitis and nasal perforations. Molecular associations and mechanisms are emphasised to assist pathologists to put their observations into the context of clinical, genetic and environmental influences on patients’ diseases.
Literature
1.
go back to reference deShazo RD, O’Brien MM, Justice WK, Pitcock J. Diagnostic criteria for sarcoidosis of the sinuses. J Allergy Clin Immunol. 1999;103(5 Pt 1):789–95.CrossRefPubMed deShazo RD, O’Brien MM, Justice WK, Pitcock J. Diagnostic criteria for sarcoidosis of the sinuses. J Allergy Clin Immunol. 1999;103(5 Pt 1):789–95.CrossRefPubMed
2.
go back to reference Lawson W, Jiang N, Cheng J. Sinonasal sarcoidosis: a new system of classification acting as a guide to diagnosis and treatment. Am J Rhinol Allergy. 2014;28(4):317–22.CrossRefPubMed Lawson W, Jiang N, Cheng J. Sinonasal sarcoidosis: a new system of classification acting as a guide to diagnosis and treatment. Am J Rhinol Allergy. 2014;28(4):317–22.CrossRefPubMed
3.
go back to reference Adrianto I, Lin CP, Hale JJ, Levin AM, Datta I, Parker R, et al. Genome-wide association study of African and European Americans implicates multiple shared and ethnic specific loci in sarcoidosis susceptibility. PLoS One. 2012;7(8):e43907.PubMedCentralCrossRefPubMed Adrianto I, Lin CP, Hale JJ, Levin AM, Datta I, Parker R, et al. Genome-wide association study of African and European Americans implicates multiple shared and ethnic specific loci in sarcoidosis susceptibility. PLoS One. 2012;7(8):e43907.PubMedCentralCrossRefPubMed
4.
go back to reference Montone KT. The molecular genetics of inflammatory, autoimmune, and infectious diseases of the sinonasal tract: a review. Arch Pathol Lab Med. 2014;138(6):745–53.CrossRefPubMed Montone KT. The molecular genetics of inflammatory, autoimmune, and infectious diseases of the sinonasal tract: a review. Arch Pathol Lab Med. 2014;138(6):745–53.CrossRefPubMed
5.
go back to reference Fischer A, Ellinghaus D, Nutsua M, Hofmann S, Montgomery CG, Iannuzzi MC, et al. Identification of immune-relevant factors conferring sarcoidosis genetic risk. Am J Respir Crit Care Med. 2015;192(6):727–36.CrossRefPubMed Fischer A, Ellinghaus D, Nutsua M, Hofmann S, Montgomery CG, Iannuzzi MC, et al. Identification of immune-relevant factors conferring sarcoidosis genetic risk. Am J Respir Crit Care Med. 2015;192(6):727–36.CrossRefPubMed
6.
go back to reference Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, et al. 2012 revised international Chapel Hill consensus conference nomenclature of vasculitides. Arthritis Rheum. 2013;65(1):1–11.CrossRefPubMed Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, et al. 2012 revised international Chapel Hill consensus conference nomenclature of vasculitides. Arthritis Rheum. 2013;65(1):1–11.CrossRefPubMed
7.
go back to reference Korkmaz B, Lesner A, Letast S, Mahdi YK, Jourdan ML, Dallet-Choisy S, et al. Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis). Semin Immunopathol. 2013;35(4):411–21.CrossRefPubMed Korkmaz B, Lesner A, Letast S, Mahdi YK, Jourdan ML, Dallet-Choisy S, et al. Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis). Semin Immunopathol. 2013;35(4):411–21.CrossRefPubMed
8.
go back to reference Tarabishy AB, Schulte M, Papaliodis GN, Hoffman GS. Wegener’s granulomatosis: clinical manifestations, differential diagnosis, and management of ocular and systemic disease. Surv Ophthalmol. 2010;55(5):429–44.CrossRefPubMed Tarabishy AB, Schulte M, Papaliodis GN, Hoffman GS. Wegener’s granulomatosis: clinical manifestations, differential diagnosis, and management of ocular and systemic disease. Surv Ophthalmol. 2010;55(5):429–44.CrossRefPubMed
9.
go back to reference Almouhawis HA, Leao JC, Fedele S, Porter SR. Wegener’s granulomatosis: a review of clinical features and an update in diagnosis and treatment. J Oral Pathol Med. 2013;42(7):507–16.CrossRefPubMed Almouhawis HA, Leao JC, Fedele S, Porter SR. Wegener’s granulomatosis: a review of clinical features and an update in diagnosis and treatment. J Oral Pathol Med. 2013;42(7):507–16.CrossRefPubMed
10.
go back to reference Churg J, Strauss L. Allergic granulomatosis, allergic angiitis, and periarteritis nodosa. Am J Pathol. 1951;27(2):277–301.PubMedCentralPubMed Churg J, Strauss L. Allergic granulomatosis, allergic angiitis, and periarteritis nodosa. Am J Pathol. 1951;27(2):277–301.PubMedCentralPubMed
11.
12.
go back to reference Groh M, Pagnoux C, Baldini C, Bel E, Bottero P, Cottin V, et al. Eosinophilic granulomatosis with polyangiitis (Churg–Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management. Eur J Intern Med. 2015;26(7):545–53.CrossRefPubMed Groh M, Pagnoux C, Baldini C, Bel E, Bottero P, Cottin V, et al. Eosinophilic granulomatosis with polyangiitis (Churg–Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management. Eur J Intern Med. 2015;26(7):545–53.CrossRefPubMed
13.
go back to reference Arnaud L, Mathian A, Haroche J, Gorochov G, Amoura Z. Pathogenesis of relapsing polychondritis: a 2013 update. Autoimmun Rev. 2014;13(2):90–5.CrossRefPubMed Arnaud L, Mathian A, Haroche J, Gorochov G, Amoura Z. Pathogenesis of relapsing polychondritis: a 2013 update. Autoimmun Rev. 2014;13(2):90–5.CrossRefPubMed
14.
go back to reference Kotter I, Deuter C, Gunaydin I, Zierhut M. MAGIC or not MAGIC—does the MAGIC (mouth and genital ulcers with inflamed cartilage) syndrome really exist? A case report and review of the literature. Clin Exp Rheumatol. 2006;24(5 Suppl 42):S108–12.PubMed Kotter I, Deuter C, Gunaydin I, Zierhut M. MAGIC or not MAGIC—does the MAGIC (mouth and genital ulcers with inflamed cartilage) syndrome really exist? A case report and review of the literature. Clin Exp Rheumatol. 2006;24(5 Suppl 42):S108–12.PubMed
15.
go back to reference Cantarini L, Vitale A, Brizi MG, Caso F, Frediani B, Punzi L, et al. Diagnosis and classification of relapsing polychondritis. J Autoimmun. 2014;48–49:53–9.CrossRefPubMed Cantarini L, Vitale A, Brizi MG, Caso F, Frediani B, Punzi L, et al. Diagnosis and classification of relapsing polychondritis. J Autoimmun. 2014;48–49:53–9.CrossRefPubMed
16.
go back to reference Rimmer J, Andrews P, Lund VJ. Eosinophilic angiocentric fibrosis of the nose and sinuses. J Laryngol Otol. 2014;128(12):1071–7.CrossRefPubMed Rimmer J, Andrews P, Lund VJ. Eosinophilic angiocentric fibrosis of the nose and sinuses. J Laryngol Otol. 2014;128(12):1071–7.CrossRefPubMed
17.
18.
go back to reference Kosarac O, Luna MA, Ro JY, Ayala AG. Eosinophilic angiocentric fibrosis of the sinonasal tract. Ann Diagn Pathol. 2008;12(4):267–70.CrossRefPubMed Kosarac O, Luna MA, Ro JY, Ayala AG. Eosinophilic angiocentric fibrosis of the sinonasal tract. Ann Diagn Pathol. 2008;12(4):267–70.CrossRefPubMed
19.
go back to reference Settipane RA, Peters AT, Chandra R. Chapter 4: chronic rhinosinusitis. Am J Rhinol Allergy. 2013;27(Suppl 1):S11–5.CrossRefPubMed Settipane RA, Peters AT, Chandra R. Chapter 4: chronic rhinosinusitis. Am J Rhinol Allergy. 2013;27(Suppl 1):S11–5.CrossRefPubMed
20.
21.
go back to reference Escudier E, Duquesnoy P, Papon JF, Amselem S. Ciliary defects and genetics of primary ciliary dyskinesia. Paediatr Respir Rev. 2009;10(2):51–4.CrossRefPubMed Escudier E, Duquesnoy P, Papon JF, Amselem S. Ciliary defects and genetics of primary ciliary dyskinesia. Paediatr Respir Rev. 2009;10(2):51–4.CrossRefPubMed
22.
go back to reference Shusterman D. Occupational irritant and allergic rhinitis. Curr Allergy Asthma Rep. 2014;14(4):425.CrossRefPubMed Shusterman D. Occupational irritant and allergic rhinitis. Curr Allergy Asthma Rep. 2014;14(4):425.CrossRefPubMed
23.
24.
go back to reference Toppila-Salmi S, van Drunen CM, Fokkens WJ, Golebski K, Mattila P, Joenvaara S, et al. Molecular mechanisms of nasal epithelium in rhinitis and rhinosinusitis. Curr Allergy Asthma Rep. 2015;15(2):495.PubMedCentralCrossRefPubMed Toppila-Salmi S, van Drunen CM, Fokkens WJ, Golebski K, Mattila P, Joenvaara S, et al. Molecular mechanisms of nasal epithelium in rhinitis and rhinosinusitis. Curr Allergy Asthma Rep. 2015;15(2):495.PubMedCentralCrossRefPubMed
25.
go back to reference Ellis AK, Keith PK. Nonallergic rhinitis with eosinophilia syndrome. Curr Allergy Asthma Rep. 2006;6(3):215–20.CrossRefPubMed Ellis AK, Keith PK. Nonallergic rhinitis with eosinophilia syndrome. Curr Allergy Asthma Rep. 2006;6(3):215–20.CrossRefPubMed
26.
go back to reference Nassef M, Shapiro G, Casale TB. Respiratory, allergic disease F. Identifying and managing rhinitis and its subtypes: allergic and nonallergic components—a consensus report and materials from the Respiratory and Allergic Disease Foundation. Curr Med Res Opin. 2006;22(12):2541–8.CrossRefPubMed Nassef M, Shapiro G, Casale TB. Respiratory, allergic disease F. Identifying and managing rhinitis and its subtypes: allergic and nonallergic components—a consensus report and materials from the Respiratory and Allergic Disease Foundation. Curr Med Res Opin. 2006;22(12):2541–8.CrossRefPubMed
27.
go back to reference Bachert C, Van Bruaene N, Toskala E, Zhang N, Olze H, Scadding G, et al. Important research questions in allergy and related diseases: 3-chronic rhinosinusitis and nasal polyposis—a GALEN study. Allergy. 2009;64(4):520–33.CrossRefPubMed Bachert C, Van Bruaene N, Toskala E, Zhang N, Olze H, Scadding G, et al. Important research questions in allergy and related diseases: 3-chronic rhinosinusitis and nasal polyposis—a GALEN study. Allergy. 2009;64(4):520–33.CrossRefPubMed
28.
go back to reference Huvenne W, van Bruaene N, Zhang N, van Zele T, Patou J, Gevaert P, et al. Chronic rhinosinusitis with and without nasal polyps: what is the difference? Curr Allergy Asthma Rep. 2009;9(3):213–20.CrossRefPubMed Huvenne W, van Bruaene N, Zhang N, van Zele T, Patou J, Gevaert P, et al. Chronic rhinosinusitis with and without nasal polyps: what is the difference? Curr Allergy Asthma Rep. 2009;9(3):213–20.CrossRefPubMed
29.
go back to reference Pawankar R, Nonaka M. Inflammatory mechanisms and remodeling in chronic rhinosinusitis and nasal polyps. Curr Allergy Asthma Rep. 2007;7(3):202–8.CrossRefPubMed Pawankar R, Nonaka M. Inflammatory mechanisms and remodeling in chronic rhinosinusitis and nasal polyps. Curr Allergy Asthma Rep. 2007;7(3):202–8.CrossRefPubMed
30.
go back to reference Ardehali MM, Amali A, Bakhshaee M, Madani Z, Amiri M. The comparison of histopathological characteristics of polyps in asthmatic and nonasthmatic patients. Otolaryngol Head Neck Surg. 2009;140(5):748–51.CrossRefPubMed Ardehali MM, Amali A, Bakhshaee M, Madani Z, Amiri M. The comparison of histopathological characteristics of polyps in asthmatic and nonasthmatic patients. Otolaryngol Head Neck Surg. 2009;140(5):748–51.CrossRefPubMed
32.
go back to reference Castano R, Theriault G, Gautrin D. Categorizing nasal septal perforations of occupational origin as cases of corrosive rhinitis. Am J Ind Med. 2007;50(2):150–3.CrossRefPubMed Castano R, Theriault G, Gautrin D. Categorizing nasal septal perforations of occupational origin as cases of corrosive rhinitis. Am J Ind Med. 2007;50(2):150–3.CrossRefPubMed
33.
go back to reference Trimarchi M, Bertazzoni G, Bussi M. Cocaine induced midline destructive lesions. Rhinology. 2014;52(2):104–11.PubMed Trimarchi M, Bertazzoni G, Bussi M. Cocaine induced midline destructive lesions. Rhinology. 2014;52(2):104–11.PubMed
Metadata
Title
Non-infectious Inflammatory Lesions of the Sinonasal Tract
Author
Timothy R. Helliwell
Publication date
01-03-2016
Publisher
Springer US
Published in
Head and Neck Pathology / Issue 1/2016
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-016-0689-6

Other articles of this Issue 1/2016

Head and Neck Pathology 1/2016 Go to the issue

Special Issue: Sinonasal Tract Pathology. Guest Editors: Justin Bishop, MD and Alessandro Franchi, MD

Pathology of Fungal Rhinosinusitis: A Review

Special Issue: Sinonasal Tract Pathology. Guest Editors: Justin Bishop, MD and Alessandro Franchi, MD

Radiologic Features of Sinonasal Tumors

Special Issue: Sinonasal Tract Pathology. Guest Editors: Justin Bishop, MD and Alessandro Franchi, MD

Sinonasal Squamous Cell Carcinoma: A Review with Emphasis on Emerging Histologic Subtypes and the Role of Human Papillomavirus

Special Issue: Sinonasal Tract Pathology. Guest Editors: Justin Bishop, MD and Alessandro Franchi, MD

Update on Select Benign Mesenchymal and Meningothelial Sinonasal Tract Lesions

Special Issue: Sinonasal Tract Pathology. Guest Editors: Justin Bishop, MD and Alessandro Franchi, MD

An Update on Sinonasal Round Cell Undifferentiated Tumors

Special Issue: Sinonasal Tract Pathology. Guest Editors: Justin Bishop, MD and Alessandro Franchi, MD

Endonasal Endoscopic Surgery in the Management of Sinonasal and Anterior Skull Base Malignancies