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Open Access 01-02-2015 | RHINOSINUSITIS (J MULLOL, SECTION EDITOR)

Molecular Mechanisms of Nasal Epithelium in Rhinitis and Rhinosinusitis

Authors: Sanna Toppila-Salmi, Cornelis M. van Drunen, Wytske J. Fokkens, Korneliuz Golebski, Pirkko Mattila, Sakari Joenvaara, Jutta Renkonen, Risto Renkonen

Published in: Current Allergy and Asthma Reports | Issue 2/2015

Abstract

Allergic rhinitis, nonallergic rhinitis, and chronic rhinosinusitis are multifactorial upper airway diseases with high prevalence. Several genetic and environmental factors are proposed to predispose to the pathogenesis of the inflammatory upper airway diseases. Still, the molecular mechanisms leading toward the onset and progression of upper airway diseases are largely unknown. The upper airway epithelium has an important role in sensing the environment and regulating the inhaled air. As such, it links environmental insults to the host immunity. Human sinonasal epithelium serves as an excellent target for observing induced early-phase events, in vivo, and with a systems biological perspective. Actually, increasing number of investigations have provided evidence that altered homeostasis in the sinonasal epithelium might be important in the chronic upper airway inflammation.

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Title: Molecular Mechanisms of Nasal Epithelium in Rhinitis and Rhinosinusitis
Authors: Sanna Toppila-Salmi
Cornelis M. van Drunen
Wytske J. Fokkens
Korneliuz Golebski
Pirkko Mattila
Sakari Joenvaara
Jutta Renkonen
Risto Renkonen
Publication date: 01-02-2015
Publisher: Springer US
Published in: Current Allergy and Asthma Reports / Issue 2/2015
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-014-0495-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Molecular Mechanisms of Nasal Epithelium in Rhinitis and Rhinosinusitis

Abstract

At a glance: The ONWARDS insulin icodec trials

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Abstract

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