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Head and Neck Pathology
Published in: Head and Neck Pathology 1/2016

01-03-2016 | Special Issue: Sinonasal Tract Pathology. Guest Editors: Justin Bishop, MD and Alessandro Franchi, MD

Newly Described Tumor Entities in Sinonasal Tract Pathology

Author: Justin A. Bishop

Published in: Head and Neck Pathology | Issue 1/2016

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Abstract

Surgical pathology of the sinonasal tract (nasal cavity and paranasal sinuses) is extremely challenging due in part to the tremendous diversity of tumor types that may arise in this region. Compounding the difficulty, a number of new sinonasal tumor entities have been recently described, and pathologists may not yet be familiar with these neoplasms. This manuscript will review the clinicopathologic features of some of the newly described sinonasal tumor types: NUT midline carcinoma, HPV-related carcinoma with adenoid cystic-like features, SMARCB1 (INI-1) deficient sinonasal carcinoma, biphenotypic sinonasal sarcoma, and renal cell-like adenocarcinoma.
Literature
1.
Barnes L, Tse LLY, Hunt JL, et al. Tumours of the nasal cavity and paranasal sinuses: introduction. In: Barnes L, Eveson JW, Reichart P, et al., editors. World Health Organization classification of tumours: pathology and genetics of head and neck tumours. Lyon: IARC Press; 2005. p. 12–5.
2.
Kees UR, Mulcahy MT, Willoughby ML. Intrathoracic carcinoma in an 11-year-old girl showing a translocation t(15;19). Am J Pediatr Hematol Oncol. 1991;13:459–64.CrossRefPubMed
3.
Kubonishi I, Takehara N, Iwata J, et al. Novel t(15;19)(q15;p13) chromosome abnormality in a thymic carcinoma. Cancer Res. 1991;51:3327–8.PubMed
4.
5.
6.
7.
Bauer DE, Mitchell CM, Strait KM, et al. Clinicopathologic features and long-term outcomes of NUT midline carcinoma. Clin Cancer Res. 2012;18:5773–9.PubMedCentralCrossRefPubMed
8.
French CA, Ramirez CL, Kolmakova J, et al. BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells. Oncogene. 2008;27:2237–42.CrossRefPubMed
9.
10.
11.
Stelow EB, Bellizzi AM, Taneja K, et al. NUT rearrangement in undifferentiated carcinomas of the upper aerodigestive tract. Am J Surg Pathol. 2008;32:828–34.CrossRefPubMed
12.
Tilson MP, Bishop JA. Utility of p40 in the differential diagnosis of small round blue cell tumors of the sinonasal tract. Head Neck Pathol. 2014;8:141–5.PubMedCentralCrossRefPubMed
13.
14.
Solomon LW, Magliocca KR, Cohen C, et al. Retrospective analysis of nuclear protein in testis (NUT) midline carcinoma in the upper aerodigestive tract and mediastinum. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;119:213–20.CrossRefPubMed
15.
Stelow EB, French CA. Carcinomas of the upper aerodigestive tract with rearrangement of the nuclear protein of the testis (NUT) gene (NUT midline carcinomas). Adv Anat Pathol. 2009;16:92–6.CrossRefPubMed
16.
17.
Marur S, D’Souza G, Westra WH, et al. HPV-associated head and neck cancer: a virus-related cancer epidemic. Lancet Oncol. 2010;11:781–9.CrossRefPubMed
18.
Ukpo OC, Flanagan JJ, Ma XJ, et al. High-risk human papillomavirus E6/E7 mRNA detection by a novel in situ hybridization assay strongly correlates with p16 expression and patient outcomes in oropharyngeal squamous cell carcinoma. Am J Surg Pathol. 2011;35:1343–50.CrossRefPubMed
19.
Singhi AD, Westra WH. Comparison of human papillomavirus in situ hybridization and p16 immunohistochemistry in the detection of human papillomavirus-associated head and neck cancer based on a prospective clinical experience. Cancer. 2010;116:2166–73.PubMed
20.
Bishop JA, Ma XJ, Wang H, et al. Detection of transcriptionally active high-risk HPV in patients with head and neck squamous cell carcinoma as visualized by a novel E6/E7 mRNA in situ hybridization method. Am J Surg Pathol. 2012;36:1874–82.PubMedCentralCrossRefPubMed
21.
Poling JS, Ma XJ, Bui S, et al. Human papillomavirus (HPV) status of non-tobacco related squamous cell carcinomas of the lateral tongue. Oral Oncol. 2014;50:306–10.PubMedCentralCrossRefPubMed
22.
Lewis JS Jr, Ukpo OC, Ma XJ, et al. Transcriptionally-active high-risk human papillomavirus is rare in oral cavity and laryngeal/hypopharyngeal squamous cell carcinomas: a tissue microarray study utilizing E6/E7 mRNA in situ hybridization. Histopathology. 2012;60:982–91.CrossRefPubMed
23.
Lewis JS Jr, Westra WH, Thompson LD, et al. The sinonasal tract: another potential “hot spot” for carcinomas with transcriptionally-active human papillomavirus. Head Neck Pathol. 2014;8(3):241–9.PubMedCentralCrossRefPubMed
24.
25.
Larque AB, Hakim S, Ordi J, et al. High-risk human papillomavirus is transcriptionally active in a subset of sinonasal squamous cell carcinomas. Mod Pathol. 2014;27(3):343–51.PubMed
26.
Bishop JA, Ogawa T, Stelow EB, et al. Human papillomavirus-related carcinoma with adenoid cystic-like features: a peculiar variant of head and neck cancer restricted to the sinonasal tract. Am J Surg Pathol. 2013;37:836–44.PubMedCentralCrossRefPubMed
27.
Hwang SJ, Ok S, Lee HM, et al. Human papillomavirus-related carcinoma with adenoid cystic-like features of the inferior turbinate: a case report. Auris Nasus Larynx. 2015;42:53–5.CrossRefPubMed
28.
Bishop JA, Yonescu R, Batista D, et al. Mucoepidermoid carcinoma does not harbor transcriptionally active high risk human papillomavirus even in the absence of the MAML2 translocation. Head Neck Pathol. 2014;8(3):287-90.
29.
Persson M, Andren Y, Moskaluk CA, et al. Clinically significant copy number alterations and complex rearrangements of MYB and NFIB in head and neck adenoid cystic carcinoma. Genes Chromosomes Cancer. 2012;51:805–17.CrossRefPubMed
30.
Brill LB 2nd, Kanner WA, Fehr A, et al. Analysis of MYB expression and MYB-NFIB gene fusions in adenoid cystic carcinoma and other salivary neoplasms. Mod Pathol. 2011;24:1169–76.CrossRefPubMed
31.
Boland JM, McPhail ED, Garcia JJ, et al. Detection of human papilloma virus and p16 expression in high-grade adenoid cystic carcinoma of the head and neck. Mod Pathol. 2012;25:529–36.CrossRefPubMed
32.
Biegel JA, Kalpana G, Knudsen ES, et al. The role of INI1 and the SWI/SNF complex in the development of rhabdoid tumors: meeting summary from the workshop on childhood atypical teratoid/rhabdoid tumors. Cancer Res. 2002;62:323–8.PubMed
33.
Biegel JA, Zhou JY, Rorke LB, et al. Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors. Cancer Res. 1999;59:74–9.PubMed
34.
Rorke LB, Packer RJ, Biegel JA. Central nervous system atypical teratoid/rhabdoid tumors of infancy and childhood: definition of an entity. J Neurosurg. 1996;85:56–65.CrossRefPubMed
35.
Biegel JA, Burk CD, Parmiter AH, et al. Molecular analysis of a partial deletion of 22q in a central nervous system rhabdoid tumor. Genes Chromosomes Cancer. 1992;5:104–8.CrossRefPubMed
36.
Biegel JA, Rorke LB, Emanuel BS. Monosomy 22 in rhabdoid or atypical teratoid tumors of the brain. N Engl J Med. 1989;321:906.PubMed
37.
Shashi V, Lovell MA, von Kap-herr C, et al. Malignant rhabdoid tumor of the kidney: involvement of chromosome 22. Genes Chromosomes Cancer. 1994;10:49–54.CrossRefPubMed
38.
Schofield DE, Beckwith JB, Sklar J. Loss of heterozygosity at chromosome regions 22q11-12 and 11p15.5 in renal rhabdoid tumors. Genes Chromosomes Cancer. 1996;15:10–7.CrossRefPubMed
39.
Hornick JL, Dal Cin P, Fletcher CD. Loss of INI1 expression is characteristic of both conventional and proximal-type epithelioid sarcoma. Am J Surg Pathol. 2009;33:542–50.CrossRefPubMed
40.
Modena P, Lualdi E, Facchinetti F, et al. SMARCB1/INI1 tumor suppressor gene is frequently inactivated in epithelioid sarcomas. Cancer Res. 2005;65:4012–9.CrossRefPubMed
41.
Le Loarer F, Zhang L, Fletcher CD, et al. Consistent SMARCB1 homozygous deletions in epithelioid sarcoma and in a subset of myoepithelial carcinomas can be reliably detected by FISH in archival material. Genes Chromosomes Cancer. 2014;53(6):475–86.PubMedCentralCrossRefPubMed
42.
Cheng JX, Tretiakova M, Gong C, et al. Renal medullary carcinoma: rhabdoid features and the absence of INI1 expression as markers of aggressive behavior. Mod Pathol. 2008;21:647–52.CrossRefPubMed
43.
Gleason BC, Fletcher CD. Myoepithelial carcinoma of soft tissue in children: an aggressive neoplasm analyzed in a series of 29 cases. Am J Surg Pathol. 2007;31:1813–24.CrossRefPubMed
44.
Kohashi K, Oda Y, Yamamoto H, et al. SMARCB1/INI1 protein expression in round cell soft tissue sarcomas associated with chromosomal translocations involving EWS: a special reference to SMARCB1/INI1 negative variant extraskeletal myxoid chondrosarcoma. Am J Surg Pathol. 2008;32:1168–74.CrossRefPubMed
45.
Agaimy A, Rau TT, Hartmann A, et al. SMARCB1 (INI1)-negative rhabdoid carcinomas of the gastrointestinal tract: clinicopathologic and molecular study of a highly aggressive variant with literature review. Am J Surg Pathol. 2014;38(7):910–20.CrossRefPubMed
46.
47.
Frierson HF Jr, Mills SE, Fechner RE, et al. Sinonasal undifferentiated carcinoma. An aggressive neoplasm derived from schneiderian epithelium and distinct from olfactory neuroblastoma. Am J Surg Pathol. 1986;10:771–9.CrossRefPubMed
48.
Agaimy A, Koch M, Lell M, et al. SMARCB1(INI1)-deficient sinonasal basaloid carcinoma: a novel member of the expanding family of SMARCB1-deficient neoplasms. Am J Surg Pathol. 2014;38:1274–81.PubMedCentralCrossRefPubMed
49.
Lewis JT, Oliveira AM, Nascimento AG, et al. Low-grade sinonasal sarcoma with neural and myogenic features: a clinicopathologic analysis of 28 cases. Am J Surg Pathol. 2012;36:517–25.CrossRefPubMed
50.
51.
Huang SC, Ghossein RA, Bishop JA, et al. Novel PAX3-NCOA1 fusions in biphenotypic sinonasal sarcoma with focal rhabdomyoblastic differentiation. Am J Surg Pathol. 2016;40(1):51–9.CrossRefPubMed
52.
Powers KA, Han LM, Chiu AG, et al. Low-grade sinonasal sarcoma with neural and myogenic features-diagnostic challenge and pathogenic insight. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;119:e265–9.CrossRefPubMed
53.
Hasegawa SL, Mentzel T, Fletcher CD. Schwannomas of the sinonasal tract and nasopharynx. Mod Pathol. 1997;10:777–84.PubMed
54.
Terzic A, Bode B, Gratz KW, et al. Prognostic factors for the malignant triton tumor of the head and neck. Head Neck. 2009;31:679–88.CrossRefPubMed
55.
Zur KB, Brandwein M, Wang B, et al. Primary description of a new entity, renal cell-like carcinoma of the nasal cavity: van Meegeren in the house of Vermeer. Arch Otolaryngol Head Neck Surg. 2002;128:441–7.CrossRefPubMed
56.
57.
Moh’d Hadi U, Kahwaji GJ, Mufarrij AA, et al. Low grade primary clear cell carcinoma of the sinonasal tract. Rhinology. 2002;40:44–7.PubMed
58.
59.
Antonescu CR, Katabi N, Zhang L, et al. EWSR1-ATF1 fusion is a novel and consistent finding in hyalinizing clear-cell carcinoma of salivary gland. Genes Chromosomes Cancer. 2011;50:559–70.CrossRefPubMed
60.
Okabe M, Miyabe S, Nagatsuka H, et al. MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma. Clin Cancer Res. 2006;12:3902–7.CrossRefPubMed
Metadata
Title
Newly Described Tumor Entities in Sinonasal Tract Pathology
Author
Justin A. Bishop
Publication date
01-03-2016
Publisher
Springer US
Published in
Head and Neck Pathology / Issue 1/2016
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-016-0688-7

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