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Head and Neck Pathology
Published in: Head and Neck Pathology 3/2015

01-09-2015 | Review Paper

Functional Histology of Salivary Gland Pleomorphic Adenoma: An Appraisal

Authors: Asterios Triantafyllou, Lester D. R. Thompson, Kenneth O. Devaney, Diana Bell, Jennifer L. Hunt, Alessandra Rinaldo, Vincent Vander Poorten, Alfio Ferlito

Published in: Head and Neck Pathology | Issue 3/2015

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Abstract

The complex microstructure of salivary gland pleomorphic adenoma is examined in relation to function. Events related to secretion of macromolecules and absorption, responses to the altered microenvironment and controversies concerning epithelial–mesenchymal transition versus modified myoepithelial differentiation are explored. Their effects on tumor cell phenotypes and arrangements are emphasized. Heterotopic differentiation and attempts at organogenesis are also considered. The approach allows interpreting microstructure independently of histogenetic perceptions, envisaging the tumor cells as a continuum, endorsing luminal structures as the principal components, and defining pleomorphic adenoma as a benign epithelial tumour characterized by variable epithelial–mesenchymal transition, secretion/differentiation and metaplasia.
Literature
1.
Harrison JD. Minor salivary glands of man: enzyme and mucosubstance histochemical studies. Histochem J. 1974;6(6):633–47.CrossRefPubMed
2.
Triantafyllou A, Fletcher D, Scott J. Morphological phenotypes and functional capabilities of submandibular parenchymal cells of the ferret investigated by protein, mucosubstance and enzyme histochemistry. Histochem J. 1999;31(12):789–96.CrossRefPubMed
3.
Hand AR. Functional ultrastructure of the salivary glands. In: Sreebny LM, editor. The salivary system. Boca Raton: CRC Press; 1987. p. 43–67.
4.
5.
Masson P. Human tumors. Histology, diagnosis and technique. 2nd ed. Detroit: Wayne State University Press; 1970.
6.
Willis RA. Pathology of tumours. 4th ed. London: Butterworths; 1967.
7.
Seifert G, Langrock I, Donath K. Pathomorphologische Subklassifikation der pleomorphen Speichedrüsenadenome. Analyse von 310 pleomorphen Parotisadenomen. HNO. 1976;24(12):415–26.PubMed
8.
Seifert G, Rieb H, Donath K. Klassifikation der Tumoren der kleinen Speicheldrüsen Pathohistologische Analyse von 160 Tumoren. Laryngol Rhinol Otol (Stuttg). 1980;59(7):379–400.CrossRef
9.
Zbären P, Vander Poorten V, Witt RL, Woolgar JA, Shaha AR, Triantafyllou A, Takes RP, Rinaldo A, Ferlito A. Pleomorphic adenoma of the parotid: formal parotidectomy or limited surgery? Am J Surg. 2013;205(1):109–18.CrossRefPubMed
10.
Erlandson RA, Cardon-Cardo C, Higgins PJ. Histogenesis of benign pleomorphic adenoma (mixed tumor) of the major salivary glands. An ultrastructural and immunohistochemical study. Am J Surg Pathol. 1984;8(11):803–20.CrossRefPubMed
11.
Dardick I, van Nostrand AW, Phillips MJ. Histogenesis of salivary gland pleomorphic adenoma (mixed tumor) with an evaluation of the role of the myoepithelial cell. Hum Pathol. 1982;13(1):62–75.CrossRefPubMed
12.
Mori M, Tsukitani K, Ninomiya T, Okada Y. Various expressions of modified myoepithelial cells in salivary pleomorphic adenoma. Immunohistochemical studies. Pathol Res Pract. 1987;182(5):632–46.CrossRefPubMed
13.
Dardick I, van Nostrand AW, Jeans MT, Rippstein P, Edwards V. Pleomorphic adenoma, I: ultrastructural organization of “epithelial” regions. Hum Pathol. 1983;14(9):780–97.CrossRefPubMed
14.
Triantafyllou A, Hunt JL, Devaney KO, Ferlito A. A perspective of comparative salivary and breast pathology. Part I: microstructural aspects, adaptations and cellular events. Eur Arch Otorhinolaryngol. 2014;271(4):647–63.CrossRefPubMed
15.
Hamperl H. The myothelia (myoepithelial cells). Normal state; regressive changes; hyperplasia; tumors. Curr Top Pathol. 1970;53:161–220.CrossRefPubMed
16.
Thackray AC, Lucas RB. Tumors of the major salivary glands. Atlas of tumor pathology, 2nd series, fascicle 10. Washington, DC: Armed Forces Institute of Pathology; 1974.
17.
Merino MJ, LiVolsi VA. Pleomorphic adenomas of the parotid gland resembling mesenchymal tumors. Oral Surg Oral Med Oral Pathol. 1977;44(3):405–10.CrossRefPubMed
18.
Harrison JD, Auger DW. Mucosubstance histochemistry of pleomorphic adenoma of parotid and submandibular salivary glands of man: light and electron microscopy. Histochem J. 1991;23(7):293–302.CrossRefPubMed
19.
Zhao M, Takata T, Kudo Y, Sato S, Ogawa I, Wakida K, Uchida T, Nikai H. Biosynthesis of glycosaminoglycans and aggrecan by tumor cells in salivary pleomorphic adenoma: ultrastructural evidence. J Oral Pathol Med. 1999;28(10):442–50.CrossRefPubMed
20.
Kusafuka K, Ishiwata T, Sugisaki Y, Takemura T, Kusafuka M, Hisha H, Ikehara S. Lumican expression is associated with the formation of mesenchyme-like elements in salivary pleomorphic adenomas. J Pathol. 2004;203(4):953–60.CrossRefPubMed
21.
Tsuneki M, Maruyama S, Yamazaki M, Essa A, Abé T, Babkair HA, Ahsan MS, Cheng J, Saku T. Podoplanin is a novel myoepithelial cell marker in pleomorphic adenoma and other salivary gland tumors with myoepithelial differentiation. Virchows Arch. 2013;462(3):297–305.CrossRefPubMed
22.
Hirokawa M, Tamura M, Horiguchi H, Wakatsuki S, Sano T. Abnormal venous structures in salivary gland tumors: vasculature characteristics of pleomorphic adenoma. APMIS. 2001;109(9):625–30.CrossRefPubMed
23.
Swelam W, Ida-Yonemochi H, Maruyama S, Ohshiro K, Cheng J, Saku T. Vascular endothelial growth factor in salivary pleomorphic adenomas: one of the reasons for their poorly vascularized stroma. Virchows Arch. 2005;446(6):653–62.CrossRefPubMed
24.
Faur AC, Lazar E, Cornianu M. Vascular endothelial growth factor (VEGF) expression and microvascular density in salivary gland tumours. APMIS. 2014;122(5):418–26.CrossRefPubMed
25.
Garrett JR. The effects of certain experimental procedures on the innervation of cat salivary glands and their relation to human pathology. Ph.D. Thesis. London: King’s College Hospital; 1965.
26.
Hayashi Y, Deguchi H, Nakahata A, Kurashima C, Hirokawa K. Immunopathological study of neuropeptide expression in human salivary gland neoplasms. Pathobiology. 1990;58(4):212–20.CrossRefPubMed
27.
Ellis GL, Auclair P. Tumors of the salivary glands. Atlas of tumor pathology. 3rd series. Fascicle 17. Washington, DC: Armed Forces Institute of Pathology; 1996.
28.
Dardick I, Van Nostrand AW, Jeans MT, Rippstein P, Edwards V. Pleomorphic adenoma, II: ultrastructural organization of “stromal” regions. Hum Pathol. 1983;14(9):798–809.CrossRefPubMed
29.
Seifert G. Histological typing of salivary gland tumours of the salivary glands. 2nd ed. Berlin: Springer; 1991.CrossRef
30.
Eveson JW, Kusafuka K, Stenman G, Nagao T. Pleomorphic adenoma. In: Barnes L, Eveson JW, Reichart P, Sidransky D, editors. World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. Lyon: IARC Press; 2005. p. 254–8.
31.
Hayward SW, Brody JR, Cunha GR. An edgewise look at basal epithelial cells: three-dimensional views of the rat prostate, mammary gland and salivary gland. Differentiation. 1996;60(4):219–27.CrossRefPubMed
32.
Fletcher D, Triantafyllou A, Scott J. Innervation and myoepithelial arrangements in the submandibular salivary gland of ferret investigated by enzyme, catecholamine and filament histochemistry. Arch Oral Biol. 1999;44(12):1035–43.CrossRefPubMed
33.
Triantafyllou A. Acinar phenotypes in salivary pleomorphic adenoma: unusual differentiation or disordered functional activity? Pathol Res Pract. 2001;197(11):743–51.CrossRefPubMed
34.
Tandler B, Erlandson RA. Giant mitochondria in a pleomorphic adenoma of the submandibular gland. Ultrastruct Pathol. 1983;4(1):85–96.CrossRefPubMed
35.
Prasad KN, Carvalho E, Edwards-Prasad J, La Rosa FG, Kumar S, Kim JH, Meyers A, Kentroti S. Establishment of human parotid pleomorphic adenoma cells in culture: morphological and biochemical characterization. In Vitro Cell Dev Biol Anim. 1994;30A(5):312–20.CrossRefPubMed
36.
Steiner MG, Kuhel WI, Carew JF, Huo J, Hoda SA, Staiano-Coico L, Schley WS. Characterization of novel cell lines from pleomorphic adenomas of the parotid gland established in a collagen gel system. Laryngoscope. 1997;107(5):654–60.CrossRefPubMed
37.
Scott J, Liu P, Smith PM. Morphological and functional characteristics of acinar atrophy and recovery in the duct-ligated parotid gland of the rat. J Dent Res. 1999;78(11):1711–9.CrossRefPubMed
38.
Dawson LJ, Field EA, Harmer AR, Smith PM. Acetylcholine-evoked calcium mobilization and ion channel activation in human labial gland acinar cells from patients with primary Sjögren’s syndrome. Clin Exp Immunol. 2001;124(3):480–5.PubMedCentralCrossRefPubMed
39.
Harrison JD, Auger DW. Ultrastructural morphology of secretory granules in pleomorphic adenoma of human parotid and submandibular salivary glands. Arch Oral Biol. 1989;34(9):759–61.CrossRefPubMed
40.
Harrison JD, Triantafyllou A, Baldwin D, Schäfer H. Histochemical and biochemical determination of calcium in pleomorphic adenoma. Virchows Arch B Cell Pathol Incl Mol Pathol. 1993;64(2):123–5.CrossRefPubMed
41.
Hand AR. The secretory process of salivary glands and pancreas. In: Riva A, Motta PM, editors. Ultrastructure of the extraparietal glands of the digestive tract. Boston: Kluwer; 1990. p. 1–17.CrossRef
42.
Warner TF, Seo IS, Azen EA, Hafez GR, Zarling TA. Immunocytochemistry of acinic cell carcinomas and mixed tumors of salivary glands. Cancer. 1985;56(9):2221–7.CrossRefPubMed
43.
Mitani H, Murase N, Mori M. Immunohistochemical demonstration of lysozyme and lactoferrin in salivary pleomorphic adenomas. Virchows Arch B Cell Pathol Incl Mol Pathol. 1989;57(4):257–65.CrossRefPubMed
44.
Mannweiler S, Beham A, Langner C. MUC1 and MUC2 expression in salivary gland tumors and in non-neoplastic salivary gland tissue. APMIS. 2003;111(10):978–84.CrossRefPubMed
45.
Gusterson BA, Lucas RB, Ormerod MG. Distribution of epithelial membrane antigen in benign and malignant lesions of the salivary glands. Virchows Arch A Pathol Anat Histol. 1982;397(2):227–33.CrossRefPubMed
46.
Vugman I, Hand AR. Quantitative immunocytochemical study of secretory protein expression in parotid glands of rats chronically treated with isoproterenol. Microsc Res Tech. 1995;31(2):106–17.CrossRefPubMed
47.
48.
Schachter M, Perret MW, Moriwaki C, Rodrigues JA. Localization of kallikrein in submandibular gland of cat, guinea pig, dog, and man by the immunoperoxidase method. J Histochem Cytochem. 1980;28(12):1295–300.CrossRefPubMed
49.
Garrett JR, Harrison JD, Kidd A, Kyriacou K, Smith RE. Kallikrein-like activity in human salivary glands and colon, including mast cells. J Physiol. 1982;334:78P.
50.
Clements JA, Willemsen NM, Myers SA, Dong Y. The tissue kallikrein family of serine proteases: functional roles in human disease and potential as clinical biomarkers. Crit Rev Clin Lab Sci. 2004;41(3):265–312.CrossRefPubMed
51.
52.
van Krieken JH. Prostate marker immunoreactivity in salivary gland neoplasms. A rare pitfall in immunohistochemistry. Am J Surg Pathol. 1993;17(4):410–4.CrossRefPubMed
53.
Fan CY, Wang J, Barnes EL. Expression of androgen receptor and prostatic specific markers in salivary duct carcinoma: an immunohistochemical analysis of 13 cases and review of the literature. Am J Surg Pathol. 2000;24(4):579–86.CrossRefPubMed
54.
Weinreb I, Simpson RH, Skálová A, Perez-Ordoňez B, Dardick I, Chetty R, Hunt JL. Ductal adenomas of salivary gland showing striated duct differentiation (‘striated duct adenoma’): a report of six cases. Histopathology. 2010;57(5):707–15.CrossRefPubMed
55.
Darling MR, Tsai S, Jackson-Boeters L, Daley TD, Diamandis EP. Human kallikrein 8 expression in salivary gland tumors. Head Neck Pathol. 2008;2(3):169–74.PubMedCentralCrossRefPubMed
56.
Darling MR, Hashem NN, Zhang I, Mohamed AB, Fung K, Kwan K, Mara TW, Daley TD, Diamandis EP. Kallikrein-related peptidase 10 expression in salivary gland tissues and tumours. Int J Biol Markers. 2012;27(4):e381–8.CrossRefPubMed
57.
Darling MR, Jackson-Boeters L, Daley TD, Diamandis EP. Human kallikrein 13 expression in salivary gland tumors. Int J Biol Markers. 2006;21(2):106–10.PubMed
58.
Hashem NN, Mara TW, Mohamed M, Zhang I, Fung K, Kwan KF, Daley TD, Diamandis EP, Darling MR. Human kallikrein 14 (KLK14) expression in salivary gland tumors. Int J Biol Markers. 2010;25(1):32–7.PubMed
59.
Buchner A, David R, Hansen LS “Hyaline cells” in pleomorphic adenoma of salivary gland origin. Oral Surg Oral Med Oral Pathol. 1981;52(5):506–12.CrossRefPubMed
60.
Nikai H, el-Bardaie AM, Takata T, Ogawa I, Ijuhin N. Histologic evaluation of myoepithelial participation in salivary gland tumors. Int J Oral Maxillofac Surg. 1986;15(5):597–605.CrossRefPubMed
61.
Crocker J, Jenkins R, Campbell J, Fuggle WJ, Shah VM. Immunohistochemical demonstration of S-100 protein in salivary gland neoplasms. J Pathol. 1985;146(2):115–21.CrossRefPubMed
62.
Zarbo RJ, Regezi JA, Batsakis JG. S-100 protein in salivary gland tumors: an immunohistochemical study of 129 cases. Head Neck Surg. 1986;8(4):268–75.CrossRefPubMed
63.
Draeger A, Nathrath WB, Lane EB, Sundström BE, Stigbrand TI. Cytokeratins, smooth muscle actin and vimentin in human normal salivary gland and pleomorphic adenomas. Immunohistochemical studies with particular reference to myoepithelial and basal cells. APMIS. 1991;99(5):405–15.CrossRefPubMed
64.
Ogawa Y, Toyosawa S, Ishida T, Ijuhin N. Keratin 14 immunoreactive cells in pleomorphic adenomas and adenoid cystic carcinomas of salivary glands. Virchows Arch. 2000;437(1):58–68.CrossRefPubMed
65.
66.
Dardick I, Stratis M, Parks WR, DeNardi FG, Kahn HJ. S-100 protein antibodies do not label normal salivary gland myoepithelium. Histogenetic implications for salivary gland tumors. Am J Pathol. 1991;138(3):619–28.PubMedCentralPubMed
67.
Chisholm DM, Waterhouse JP, Kraucunas E, Sciubba JJ. A quantitative ultrastructural study of the pleomorphic adenoma (mixed tumor) of human minor salivary glands. Cancer. 1974;34(5):1631–41.CrossRefPubMed
68.
Palmer RM, Lucas RB, Langdon JD. Ultrastructural analysis of salivary gland pleomorphic adenoma, with particular reference to myoepithelial cells. Histopathology. 1985;9(10):1061–76.CrossRefPubMed
69.
Franquemont DW, Mills SE. Plasmacytoid monomorphic adenoma of salivary glands. Absence of myogenous differentiation and comparison to spindle cell myoepithelioma. Am J Surg Pathol. 1993;17(2):146–53.CrossRefPubMed
70.
Ogawa Y, Kishino M, Atsumi Y, Kimoto M, Fukuda Y, Ishida T, Ijuhin N. Plasmacytoid cells in salivary-gland pleomorphic adenomas: evidence of luminal cell differentiation. Virchows Arch. 2003;443(5):625–34.CrossRefPubMed
71.
Masson P. The role of the neural crests in the embryonal adenosarcomas of the kidney. Am J Pathol. 1938;33(1):1–32.
72.
Triantafyllou A, Coulter P, Scott J. Phenotypes in canalicular adenoma of human minor salivary glands reflect the interplay of altered secretory product, absent neuro-effector relationships and the diversity of the microenvironment. Histopathology. 1999;35(6):502–16.CrossRefPubMed
73.
Economopoulou P, Hanby A, Odell EW. Expression of E-cadherin, cellular differentiation and polarity in epithelial salivary neoplasms. Oral Oncol. 2000;36(6):515–8.CrossRefPubMed
74.
Franchi A, Santoro R, Paglierani M, Bondi R. Immunolocalization of alpha 2, alpha 5, and alpha 6 integrin subunits in salivary tissue and adenomas of the parotid gland. J Oral Pathol Med. 1994;23(10):457–60.CrossRefPubMed
75.
Neureiter D, Böhmer J, Kirchner T, Aigner T. Pleomorphic adenomas of the parotid express different mesenchymal phenotypes: demonstration of matrix gene expression products characteristic of the fibroblastic and chondrocytic cell lineages. Histopathology. 1999;35(4):373–9.CrossRefPubMed
76.
Harrison JD, Auger DW. Ultrastructural observations on luminal structures of pleomorphic adenoma of parotid and submandibular salivary glands of man. Virchows Archiv A Pathol Anat. 1989;415(6):559–63.CrossRef
77.
Norberg L, Stratis M, Dardick I. Quantitation and localization of cycling tumor cells in pleomorphic adenomas and myoepitheliomas: an immunohistochemical analysis. J Oral Pathol Med. 1997;26(3):124–8.CrossRefPubMed
78.
Thiery JP. Epithelial–mesenchymal transitions in development and pathologies. Curr Opin Cell Biol. 2003;15(6):740–6.CrossRefPubMed
79.
Aigner T, Neureiter D, Völker U, Belke J, Kirchner T. Epithelial–mesenchymal transdifferentiation and extracellular matrix gene expression in pleomorphic adenomas of the parotid salivary gland. J Pathol. 1998;186(2):178–85.CrossRefPubMed
80.
Su L, Morgan PR, Harrison DL, Waseem A, Lane EB. Expression of keratin mRNAs and proteins in normal salivary epithelia and pleomorphic adenomas. J Pathol. 1993;171(3):173–81.CrossRefPubMed
81.
Kusafuka K, Yamaguchi A, Kayano T, Takemura T Immunohistochemical localization of members of the transforming growth factor (TGF)-beta superfamily in normal human salivary glands and pleomorphic adenomas. J Oral Pathol Med. 2001;30(7):413–20.CrossRefPubMed
82.
Nawshad A, Lagamba D, Polad A, Hay ED. Transforming growth factor-beta signaling during epithelial–mesenchymal transformation: implications for embryogenesis and tumor metastasis. Cells Tissues Organs. 2005;179(1–2):11–2.CrossRefPubMed
83.
Seifert G, Donath K, Schäfer R. Lipomatous pleomorphic adenoma of the parotid gland. Classification of lipomatous tissue in salivary glands. Pathol Res Pract. 1999;195(4):247–52.CrossRefPubMed
84.
Haskell HD, Butt KM, Woo SB. Pleomorphic adenoma with extensive lipometaplasia: report of three cases. Am J Surg Pathol. 2005;29(10):1389–93.CrossRefPubMed
85.
Garrett JR, Lenninger S, Ohlin P. Concerning possible contractile mechanisms in the pancreas—myoepithelial cells. Experientia. 1970;26(7):741.CrossRefPubMed
86.
Langman G, Andrews CL, Weissferdt A. WT1 expression in salivary gland pleomorphic adenomas: a reliable marker of the neoplastic myoepithelium. Mod Pathol. 2011;24(2):168–74.CrossRefPubMed
87.
88.
Hohenstein P, Hastie ND. The many facets of the Wilms’ tumour gene, WT1. Hum Mol Genet. 2006;15(Spec No 2):R196–201.CrossRefPubMed
89.
Cheuk W, Chan JK. Salivary gland tumors. In: Fletcher CDM, editor. Diagnostic histopathology of tumors. 3rd ed. Philadelphia: Churchill Livingstone Elsevier; 2007. p. 239–325.
90.
Buchner A, David R. Lipofuscin in salivary glands in health and disease. Oral Surg Oral Med Oral Pathol. 1978;46(1):79–86.CrossRefPubMed
91.
Matsumoto Y. Lipofuscin pigmentation in pleomorphic adenoma of the palate. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;92(3):299–302.CrossRefPubMed
92.
Harrison JD, Auger DW. Ultrastructural cytochemistry of phosphatases in the ductal component of pleomorphic adenoma of human parotid and submandibular salivary glands. Histochem J. 1982;14(5):703–11.CrossRefPubMed
93.
Metzelaar MJ, Wijngaard PL. CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells. J Biol Chem. 1991;266(5):3239–45.PubMed
94.
Ruggles N, Triantafyllou A. Lysosomal activities and cellular homeostasis in epithelial tumours of salivary glands: an immunohistochemical investigation. J Pathol. 2013;231(S1):S34.
95.
Hatakeyama S, Satoh M, Yoshimura N, Otsu T. Immunocytochemical localization of bone morphogenetic proteins (BMPs) in salivary gland pleomorphic adenoma. J Oral Pathol Med. 1994;23(5):232–6.CrossRefPubMed
96.
Vanmuylder N, Evrard L, Daelemans P, Douroy N. Chaperones in the parotid gland: localization of heat shock proteins in human adult salivary glands. Cells Tissues Organs. 2000;167(2–3):199–205.CrossRefPubMed
97.
Thrane PS, Roop DR, Sollid LM, Huitfeldt HS, Brandtzaeg P. Two-colour immunofluorescence marker study of pleomorphic adenomas. Histochemistry. 1990;93(5):459–68.CrossRefPubMed
98.
Dardick I. Color atlas/text of salivary gland tumor pathology. New York: Igaku-Shoin; 1996.
99.
Simpson RHW, Di Palma S. Selected recent advances in the pathology of salivary neoplasms. Diagn Histopathol. 2010;16(6):276–86.CrossRef
100.
Wilson JB, Madhavan A, Risk JM, Triantafyllou A. Expression of FANCD2 in epithelial tumours of salivary glands in man: an immunohistochemical investigation. J Pathol. 2012;228(S1):S28.
Metadata
Title
Functional Histology of Salivary Gland Pleomorphic Adenoma: An Appraisal
Authors
Asterios Triantafyllou
Lester D. R. Thompson
Kenneth O. Devaney
Diana Bell
Jennifer L. Hunt
Alessandra Rinaldo
Vincent Vander Poorten
Alfio Ferlito
Publication date
01-09-2015
Publisher
Springer US
Published in
Head and Neck Pathology / Issue 3/2015
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-014-0581-1

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