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01-09-2008 | Original Paper

Human Kallikrein 8 Expression in Salivary Gland Tumors

Authors: Mark R. Darling, Sam Tsai, Linda Jackson-Boeters, Thomas D. Daley, Eleftherios P. Diamandis

Published in: Head and Neck Pathology | Issue 3/2008

Abstract

The human kallikrein 8 protein (KLK8) is expressed in many normal tissues including esophagus, skin, testis, tonsil, kidney, breast, and salivary gland, and is found in biological fluids including breast milk, amniotic fluid, seminal fluid and serum. It has also been shown to be a biomarker and prognostic factor for breast cancer. The aim of this study was to determine whether KLK8 is expressed in salivary gland tissues and salivary gland tumors (both benign and malignant), in order to compare normal with tumor tissues. Pleomorphic adenomas, adenoid cystic carcinomas, polymorphous low grade adenocarcinomas, acinic cell carcinomas, mucoepidermoid carcinomas, and adenocarcinomas NOS of both minor and major salivary glands were examined. The results of this study indicate that most salivary gland tumors show high levels of expression of KLK8.

Diamandis EP, Yousef GM, Luo LY. The human kallikrein gene family—implications in carcinogenesis. Trends Endocrinol Metab. 2000;11:54–60.PubMedCrossRef

Yousef GM, Diamandis EP. The new human tissue kallikrein gene family: structure, function and association to disease. Endocr Rev. 2001;22:184–204.PubMedCrossRef

Borgono CA, Michael IP, Diamandis EP. Human tissue kallikreins: physiologic roles and applications in cancer. Mol Cancer Res. 2004;2:257–80.PubMed

Borgono CA, Diamandis EP. The emerging roles of human tissue kallikreins in cancer. Nat Rev Cancer. 2004;4:876–90.PubMedCrossRef

Yousef GM, Diamandis EP. Human tissue kallikreins: a new enzymatic cascade pathway? Biol Chem. 2002;383:1045–57.PubMedCrossRef

Rajapakse S, Ogiwara K, Takano N, et al. Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins. FEBS Lett. 2005;579:6879–84.PubMedCrossRef

Diamandis EP, Yousef GM. Human tissue kallikreins: a family of new cancer biomarkers. Clin Chem. 2002;48:1198–1205.PubMed

Diamandis EP, Yousef GM. Human tissue kallikrein gene family: a rich source of novel disease biomarkers. Expert Rev Mol Diagn. 2001;1:182–90.PubMedCrossRef

Obiezu C, Diamandis E. Human tissue kallikrein family: applications in cancer. Cancer Lett. 2005;224:1–22.PubMed

10.

Petraki CD, Papanastasiou PA, Karavana VN, et al. Cellular distribution of human tissue kallikreins: immunohistochemical localization. Biol Chem. 387;2006:653–63.PubMedCrossRef

11.

Yoshida S, Taniguchi M, Hirata A, et al. Sequence analysis and expression of human neuropsin cDNA and gene. Gene. 1998;213:9–16.PubMedCrossRef

12.

Kishi T, Grass L, Soosaipillai A, et al. Human kallikrein 8: immunoassay development and identification in tissue extracts and biological fluids. Clin Chem. 2003;49:87–96.PubMedCrossRef

13.

Ellis GL, Auclair PL. Tumors of the salivary glands. In: Rosai J, Sobin LH, editors. Atlas of tumor pathology, Third Series, Fascicle 17. Washington, D.C.: Armed Forces Institute of Pathology; 1996. p. 39–56, 155–228.

14.

Black MH, Magklara A, Obiezu CV, et al. Development of an ultrasensitive immunoassay for human glandular kallikrein with no cross-reactivity from prostate-specific antigen. Clin Chem. 1999;45:790–9.PubMed

15.

Allred DC, Clark GM, Elledge R, et al. Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer. J Natl Cancer Inst. 1993;85:200–6.PubMedCrossRef

16.

Tuck AB, O’Malley FP, Singhal H, et al. Osteopontin expression in a group of lymph node negative breast cancer patients. Int J Cancer. 1998;79:502–8.PubMedCrossRef

17.

Kishi T, Grass L, Soosaipillai A, et al. Human kallikrein 8, a novel biomarker for ovarian carcinoma. Cancer Res. 2003;63:2771–4.PubMed

18.

Yousef GM, Polymeris ME, Yacoub GM, et al. Parallel overexpression of seven kallikrein genes in ovarian cancer. Cancer Res. 2003;63:2223–7.PubMed

19.

Magklara A, Scorilas A, Katsaros D, et al. The human KLK8 (neuropsin/ovasin) gene: identification of two novel splice variants and its prognostic value in ovarian cancer. Clin Cancer Res. 2001;7:806–11.PubMed

20.

Shigemasa K, Tian X, Gu L, et al. Human kallikrein 8 (KLK8/TADG-14) expression is associated with an early clinical stage and favorable prognosis in ovarian cancer. Oncol Rep. 2004;11:1153–9.PubMed

21.

Borgono CA, Kishi T, Scorilas A, et al. Human kallikrein 8 protein is a favorable prognostic marker in ovarian cancer. Clin Cancer Res. 2006;12:1487–93.PubMedCrossRef

22.

Yousef GM, Yacoub GM, Polymeris ME, et al. Kallikrein gene downregulation in breast cancer. Br J Cancer. 2004;90:167–72.PubMedCrossRef

23.

Paliouras M, Diamandis EP. Coordinated steroid hormone-dependent and independent expression of multiple kallikreins in breast cancer cell lines. Breast Cancer Res Treat. 2007;102:7–18.PubMedCrossRef

24.

Cané S, Bignotti E, Bellone S, et al. The novel serine protease tumor-associated differentially expressed gene-14(KLK8/Neuropsin/Ovasin) is highly overexpressed in cervical cancer. Am J Obstet Gynecol. 2004;190:60–6.PubMedCrossRef

25.

Jin H, Nagai N, Shigemasa K, et al. Expression of tumor-associated differentially expressed Gene-14 (TADG-14/KLK8) and its protein KLK8 in uterine endometria and endometrial carcinomas. Tumour Biol. 2006;27:274–82.PubMedCrossRef

26.

Sher YP, Chou CC, Chou RH, et al. Human kallikrein 8 protease confers a favorable clinical outcome in non-small cell lung cancer by suppressing tumor cell invasiveness. Cancer Res. 2006;66:11763–70.PubMedCrossRef

27.

Kishi T, Cloutier SM, Kundig C, et al. Activation and enzymatic characterization of recombinant human kallikrein 8. Biol Chem. 2006;387:723–31.PubMedCrossRef

28.

Pampalakis G, Sotiropoulou G. Tissue kallikrein proteolytic cascade pathways in normal physiology and cancer. Biochim Biophys Acta. 2007;1776:22–31.PubMed

29.

Emami N, Diamandis EP. Human tissue kallikreins: a road under construction. Clin Chim Acta. 2007;381:78–84.PubMedCrossRef

30.

Yoon H, Laxmikanthan G, Lee J, et al. Activation profiles and regulatory cascades of the human kallikrein-related peptidases. J Biol Chem. 2007;282:31852–64.PubMedCrossRef

31.

Darling MR, Jackson-Boeters L, Daley TD, et al. Human kallikrein 6 expression in salivary gland tumors. J Histochem Cytochem. 2006;54:337–42.PubMedCrossRef

32.

Darling MR, Jackson-Boeters L, Daley TD, et al. Human kallikrein 13 expression in salivary gland tumors. Int J Biol Markers. 2006;21:106–10.PubMed

33.

Darling MR, Tsai S, Jackson-Boeters L, et al. Human kallikrein 3 (prostate specific antigen) and human kallikrein 5 expression in salivary gland tumors. Int J Biol Markers. 2006;21:201–5.PubMed

34.

Paliouras M, Diamandis EP. The kallikrein world: an update on the human tissue kallikreins. Biol Chem 2006;387:643–52.PubMedCrossRef

Title: Human Kallikrein 8 Expression in Salivary Gland Tumors
Authors: Mark R. Darling
Sam Tsai
Linda Jackson-Boeters
Thomas D. Daley
Eleftherios P. Diamandis
Publication date: 01-09-2008
Publisher: Humana Press Inc
Published in: Head and Neck Pathology / Issue 3/2008
Electronic ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-008-0068-z

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Human Kallikrein 8 Expression in Salivary Gland Tumors

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

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