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Indian Journal of Pediatrics
Published in: Indian Journal of Pediatrics 8/2019

01-08-2019 | Neonatal Screening | Editorial Commentary

Hypothyroxinemia in Preterm Neonates: Not Always Hypothyroidism

Author: Vijayalakshmi Bhatia

Published in: Indian Journal of Pediatrics | Issue 8/2019

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Excerpt

Thyroid physiology in preterm neonates is characterized by differences from that in the term counterpart. Challenges to interpretation of the results of newborn screening (NBS) for congenital hypothyroidism (CH) include: (a) low serum thyroxine (T4), which may mislead one to a diagnosis of CH, in T4 based NBS, and (b) falsely low TSH (or delayed rise of TSH, due to immaturity of the pituitary gland) which may lead to missed diagnosis of true CH in TSH based NBS. Besides the setting of NBS, thyroid function tests are performed for a variety of indications in the neonate; these results too may be subject to wrong interpretation. …
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Léger J, Olivieri A, Donaldson M, et al, ESPE-PES-SLEP-JSPE-APEG-APPES-ISPAE, Congenital Hypothyroidism Consensus Conference Group. European Society for Paediatric Endocrinology consensus guidelines on screening, diagnosis, and management of congenital hypothyroidism. J Clin Endocrinol Metab. 2014;99:363–84.
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Bongers-Schokking JJ, Resing WCM, Oostdijk W, de Rijke YB, de Muinck Keizer-Shrama SMPF. Relation between early over and under treatment and behavioural problems in preadolescent children with congenital hypothyroidism. Horm Res Pediatr. 2018;90:247–56.CrossRef
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Desai MP, Sharma R, Riaz I, Sudhanshu S, Parikh R, Bhatia V. Newborn screening guidelines for congenital hypothyroidism in India: recommendations of the Indian Society for Pediatric and Adolescent Endocrinology - part I: screening and confirmation of diagnosis. Indian J Pediatr. 2018;85:440–7.CrossRefPubMed
Metadata
Title
Hypothyroxinemia in Preterm Neonates: Not Always Hypothyroidism
Author
Vijayalakshmi Bhatia
Publication date
01-08-2019
Publisher
Springer India
Published in
Indian Journal of Pediatrics / Issue 8/2019
Print ISSN: 0019-5456
Electronic ISSN: 0973-7693
DOI
https://doi.org/10.1007/s12098-019-03015-1

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